Conjugation of curcumin onto alginate enhances aqueous solubility and stability of curcumin

被引：138
作者：
Dey, Soma [1 ]
Sreenivasan, K. [1 ]
机构：
[1] Sree Chitra Tirunal Inst Med Sci & Technol, Biomed Technol Wing, Lab Polymer Anal, Trivandrum 695012, Kerala, India
来源：
CARBOHYDRATE POLYMERS | 2014年 / 99卷
关键词：
Curcumin; Alginate; Polymer-drug conjugates; CMC; Cytotoxicity; PROSTATE-CANCER CELLS; DRUG-DELIVERY; NANOPARTICLES; PYRENE-1-CARBOXALDEHYDE; NANOTECHNOLOGY; APOPTOSIS;
D O I：
10.1016/j.carbpol.2013.08.067
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Curcumin is a potential drug for various diseases including cancer. Prime limitations associated with curcumin are low water solubility, rapid hydrolytic degradation and poor bioavailability. In order to redress these issues we developed Alginate-Curcumin (Alg-Ccm) conjugate which was characterized by FTIR and I H NMR spectroscopy. The conjugate self-assembled in aqueous solution forming micelles with an average hydrodynamic diameter of 459 +/- 0.32 nm and negative zeta potential. The spherical micelles were visualized by TEM. The critical micelle concentration (CMC) of Alg-Ccm conjugate was determined. A significant enhancement in the aqueous solubility of curcumin was observed upon conjugation with alginate. Formation of micelles improved the stability of curcumin in water at physiological pH. The cytotoxic activity of Alg-Ccm was quantified by MTT assay using L-929 fibroblast cells and it was found to be potentially cytotoxic. Hence, Alg-Ccm could be a promising drug conjugate as well as a nanosized delivery vehicle. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：499 / 507
页数：9
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