Doxorubicin: nanotechnological overviews from bench to bedside

被引：295

作者：

Cagel, Maximiliano ^{[1
,2
]}

Grotz, Estefania ^{[1
,2
]}

Bernabeu, Ezequiel ^{[1
,2
]}

Moretton, Marcela A. ^{[1
,2
]}

Chiappetta, Diego A. ^{[1
,2
]}

机构：

[1] Univ Buenos Aires, Fac Farm & Bioquim, Catedra Tecnol Farmaceut I, Buenos Aires, DF, Argentina

[2] Consejo Nacl Invest Cient & Tecn, Buenos Aires, DF, Argentina

来源：

DRUG DISCOVERY TODAY | 2017年 / 22卷 / 02期

关键词：

PEGYLATED-LIPOSOMAL DOXORUBICIN; ANTHRACYCLINE ANTITUMOR COMPOUNDS; PHASE-III TRIAL; CONVENTIONAL DOXORUBICIN; POLYMERIC MICELLES; ENCAPSULATED DOXORUBICIN; REDUCED CARDIOTOXICITY; MULTICENTER TRIAL; THERMAL ABLATION; 1ST-LINE THERAPY;

D O I：

10.1016/j.drudis.2016.11.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Doxorubicin (DOX) is considered one of the most effective chemotherapeutic agents, used as a first-line drug in numerous types of cancer. Nevertheless, it exhibits serious adverse effects, such as lethal cardiotoxicity and dose-limiting myelosuppression. In this review, we focus on the description and the clinical benefits of different DOX-loaded nanotechnological platforms, not only those commercially available but also the ones that are currently in clinical phases, such as liposomes, polymeric nanoparticles, polymer-drug conjugates, polymeric micelles and ligand-based DOX-loaded nanoformulations. Although some DOX-based nanoproducts are currently being used in the clinical field, it is clear that further research is necessary to achieve improvements in cancer therapeutics.

引用

页码：270 / 281

页数：12

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