Deconvoluting the Biological Roles of vitamin D-Binding Protein During Pregnancy: A Both Clinical and Theoretical Challenge

被引:37
作者
Karras, Spyridon N. [1 ]
Koufakis, Theocharis [1 ]
Fakhoury, Hana [2 ]
Kotsa, Kalliopi [1 ]
机构
[1] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Dept Internal Med 1, Div Endocrinol & Metab,Med Sch, Thessaloniki, Greece
[2] AlFaisal Univ, Coll Med, Dept Biochem & Mol Biol, Riyadh, Saudi Arabia
关键词
vitamin D-binding protein; 25-hydroxyvitamin D; Gc-globulin; pregnancy; clinical outcomes; polymorphisms; D METABOLISM; 25-HYDROXYVITAMIN D; D; 25-HYDROXYLASE; RAT-LIVER; D ANALOGS; SERUM; WOMEN; PREECLAMPSIA; LACTATION; PLASMA;
D O I
10.3389/fendo.2018.00259
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The teleological purpose of an ongoing pregnancy is to fulfill its fundamental role of a successful, uncomplicated delivery, in conjunction with an optimal intrauterine environment for the developing fetus. Vitamin D metabolism is adapted to meet both these demands during pregnancy; first by stimulation of calcium absorption for adequate intrauterine bone mineral accrual of the fetus, and second, by enhancing systemic and local maternal tolerance to paternal and fetal alloantigens. Vitamin D-binding protein (VDBP) is one of the key biomolecules that optimize vitamin D homeostasis and also contributes as an immune regulator for a healthy, ongoing pregnancy. In this regard, recent results indicate that dysregulation of VDBP equilibrium could be a risk factor for adverse fetal, maternal, and neonatal outcomes, including preeclampsia, preterm birth, and gestational diabetes. Moreover, it has been hypothesized to be also implicated in the interpretation of vitamin D status in the pregnant state. The aim of this review is to assess available literature regarding the association of VDBP with clinical outcomes during pregnancy, as a potential biomarker for future clinical practice, with a discourse on current knowledge gaps and future research agenda.
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页数:10
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