The effect of selected antioxidants on the kinetics of changes in the stability of an HTK solution:: A technical note

被引：11

作者：

Dolinska, Barbara ^{[1
]}

Ryszka, Florian ^{[1
]}

Ostrozka-Cieslik, Aneta ^{[1
]}

机构：

[1] Biochefa Pharmaceut Res & Prod Plant, PL-41200 Sosnowiec, Poland

来源：

AAPS PHARMSCITECH | 2006年 / 7卷 / 02期

关键词：

HTK solution; stability; antioxidants; vitamin C; cysteine; fumaric acid;

D O I：

10.1208/pt070251

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of selected antioxidants (vitamin C, cysteine, fumaric acid) on the stability of a 0.3-mM solution of HTK has been determined. The stability of the HTK solution was determined using the changes in histidine content at elevated temperatures. The rate of the amino acid decomposition in this solution was 42.3% lower than in a solution without an antioxidant.

引用

页数：4

共 9 条

[1]

ALEXANDER RJ, 1970, LAB MANUAL ANAL METH

[2] Rationale for the use of antioxidant vitamins in clinical organ transplantation [J].

Lehr, HA ;

Messmer, K .

TRANSPLANTATION, 1996, 62 (09) :1197-1199

[3] Preservation solutions for transplantation [J].

Mühlbacher, F ;

Langer, F ;

Mittermayer, C .

TRANSPLANTATION PROCEEDINGS, 1999, 31 (05) :2069-2070

[4] Histidine-tryptophan-ketoglutarate solution for organ preservation in human liver transplantation -: a prospective multi-centre observation study [J].

Pokorny, H ;

Rasoul-Rockenschaub, S ;

Langer, F ;

Windhager, T ;

Rosenstingl, A ;

Lange, R ;

Königsrainer, A ;

Ringe, B ;

Mühlbacher, F ;

Steininger, R .

TRANSPLANT INTERNATIONAL, 2004, 17 (05) :256-260

[5]

Shi Li, 2004, Expert Opin Drug Saf, V3, P153, DOI 10.1517/eods.3.2.153.27338

[6]

TOSHITAKA M, 1999, J BIOL CHEM, V5, P2838

[7]

*US PHARM, 1995, NATL FORMULARY S1, V23

[8]

WLODEK L, 2004, POL FARM, V9, P404

[9]

1996, INT C HARM GUID IND

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