Obesity-related cardiovascular disease: implications of obstructive sleep apnea

被引：55

作者：

Wolk, R ^{[1
]}

Somers, VK ^{[1
]}

机构：

[1] Mayo Clin, Dept Med, Div Cardiovasc Dis, Rochester, MN USA

来源：

DIABETES OBESITY & METABOLISM | 2006年 / 8卷 / 03期

关键词：

cardiovascular disease; obesity; sleep apnea;

D O I：

10.1111/j.1463-1326.2005.00508.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity and obstructive sleep apnea (OSA) often coexist. OSA has been linked to cardiovascular disease. Thus, OSA may contribute to the cardiovascular consequences of obesity. In this review, we explore clinical and pathophysiological interactions between obesity, cardiovascular disease and OSA. We discuss the mechanisms whereby OSA may contribute to hypertension, atherosclerosis, insulin resistance and atrial fibrillation associated with obesity, and emphasize the potential implications for understanding why only a subgroup of obese patients develop cardiovascular disease. Identification of the OSA-dependent and OSA-independent pathways in the cardiovascular pathophysiology of obesity may hold clinical and therapeutic promise.

引用

页码：250 / 260

页数：11

共 155 条

[61] Obstructive sleep apnea and the recurrence of atrial fibrillation [J].

Kanagala, R ;

Murali, NS ;

Friedman, PA ;

Ammash, NM ;

Gersh, BJ ;

Ballman, KV ;

Shamsuzzaman, ASM ;

Somers, VK .

CIRCULATION, 2003, 107 (20) :2589-2594

[62] RELATION OF ADIPOSITY TO BLOOD PRESSURE AND DEVELOPMENT OF HYPERTENSION [J].

KANNEL, WB ;

BRAND, N ;

SKINNER, JJ ;

DAWBER, TR ;

MCNAMARA, PM .

ANNALS OF INTERNAL MEDICINE, 1967, 67 (01) :48-+

[63]

Kato M, 2000, CIRCULATION, V102, P2607

[64] Obesity and systemic oxidative stress - Clinical correlates of oxidative stress in the Framingham Study [J].

Keaney, JF ;

Larson, MG ;

Vasan, RS ;

Wilson, PWF ;

Lipinska, I ;

Corey, D ;

Massaro, JM ;

Sutherland, P ;

Vita, JA ;

Benjamin, EJ .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (03) :434-439

[65]

Kjeldsen Sverre E., 1992, Journal of Cardiovascular Pharmacology, V20, pS32, DOI 10.1097/00005344-199200208-00008

[66] THE NATURAL-HISTORY OF ATRIAL-FIBRILLATION - INCIDENCE, RISK-FACTORS, AND PROGNOSIS IN THE MANITOBA FOLLOW-UP-STUDY [J].

KRAHN, AD ;

MANFREDA, J ;

TATE, RB ;

MATHEWSON, FAL ;

CUDDY, TE .

AMERICAN JOURNAL OF MEDICINE, 1995, 98 (05) :476-484

[67] Impairment of vascular endothelial function and left ventricular filling - Association with the severity of apnea-induced hypoxemia during sleep [J].

Kraiczi, H ;

Caidahl, K ;

Samuelsson, A ;

Peker, Y ;

Hedner, J .

CHEST, 2001, 119 (04) :1085-1091

[68] Fatty acid-induced insulin resistance: Decreased muscle PI3K activation but unchanged Akt phosphorylation [J].

Kruszynska, YT ;

Worrall, DS ;

Ofrecio, J ;

Frias, JP ;

Macaraeg, G ;

Olefsky, JM .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (01) :226-234

[69] C-reactive protein as a cardiovascular risk factor - More than an epiphenomenon? [J].

Lagrand, WK ;

Visser, CA ;

Hermens, WT ;

Niessen, HWM ;

Verheugt, FWA ;

Wolbink, GJ ;

Hack, CE .

CIRCULATION, 1999, 100 (01) :96-102

[70] The effect of altitude hypoxia on glucose homeostasis in men [J].

Larsen, JJ ;

Hansen, JM ;

Olsen, NV ;

Galbo, H ;

Dela, F .

JOURNAL OF PHYSIOLOGY-LONDON, 1997, 504 (01) :241-249

← 2 3 4 5 6 7 8 9 10 11 →