Obesity-related cardiovascular disease: implications of obstructive sleep apnea

被引：55

作者：

Wolk, R ^{[1
]}

Somers, VK ^{[1
]}

机构：

[1] Mayo Clin, Dept Med, Div Cardiovasc Dis, Rochester, MN USA

来源：

DIABETES OBESITY & METABOLISM | 2006年 / 8卷 / 03期

关键词：

cardiovascular disease; obesity; sleep apnea;

D O I：

10.1111/j.1463-1326.2005.00508.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity and obstructive sleep apnea (OSA) often coexist. OSA has been linked to cardiovascular disease. Thus, OSA may contribute to the cardiovascular consequences of obesity. In this review, we explore clinical and pathophysiological interactions between obesity, cardiovascular disease and OSA. We discuss the mechanisms whereby OSA may contribute to hypertension, atherosclerosis, insulin resistance and atrial fibrillation associated with obesity, and emphasize the potential implications for understanding why only a subgroup of obese patients develop cardiovascular disease. Identification of the OSA-dependent and OSA-independent pathways in the cardiovascular pathophysiology of obesity may hold clinical and therapeutic promise.

引用

页码：250 / 260

页数：11

共 155 条

[1] DAYTIME HYPERTENSION AND THE EFFECTS OF SHORT-TERM NASAL CONTINUOUS POSITIVE AIRWAY PRESSURE TREATMENT IN OBSTRUCTIVE SLEEP-APNEA SYNDROME [J].

AKASHIBA, T ;

KURASHINA, K ;

MINEMURA, H ;

YAMAMOTO, H ;

HORIE, T .

INTERNAL MEDICINE, 1995, 34 (06) :528-532

[2] Obesity is independently associated with coronary endothelial dysfunction in patients with normal or mildly diseased coronary arteries [J].

Al Suwaidi, J ;

Higano, ST ;

Holmes, DR ;

Lennon, R ;

Lerman, A .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2001, 37 (06) :1523-1528

[3] Plasma cytokine levels in patients with obstructive sleep apnea syndrome: a preliminary study [J].

Alberti, A ;

Sarchielli, P ;

Gallinella, E ;

Floridi, A ;

Mazzotta, G ;

Gallai, V .

JOURNAL OF SLEEP RESEARCH, 2003, 12 (04) :305-311

[4] Annual deaths attributable to obesity in the United States [J].

Allison, DB ;

Fontaine, KR ;

Manson, JE ;

Stevens, J ;

VanItallie, TB .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 282 (16) :1530-1538

[5] Sympathetic neural activation in visceral obesity [J].

Alvarez, GE ;

Beske, SD ;

Ballard, TP ;

Davy, KP .

CIRCULATION, 2002, 106 (20) :2533-2536

[6] Regulation of fasted blood glucose by resistin [J].

Banerjee, RR ;

Rangwala, SM ;

Shapiro, JS ;

Rich, AS ;

Rhoades, B ;

Qi, Y ;

Wang, J ;

Rajala, MW ;

Pocai, A ;

Scherer, PE ;

Steppan, CM ;

Ahima, RS ;

Obici, S ;

Rossetti, L ;

Lazar, MA .

SCIENCE, 2004, 303 (5661) :1195-1198

[7] Resistin: molecular history and prognosis [J].

Banerjee, RR ;

Lazar, MA .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2003, 81 (04) :218-226

[8] Obesity-associated activation of angiotensin and endothelin in the cardiovascular system [J].

Barton, M ;

Carmona, R ;

Ortmann, J ;

Krieger, JE ;

Traupe, T .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2003, 35 (06) :826-837

[9] Effect of nasal continuous positive airway pressure treatment on blood pressure in patients with obstructive sleep apnea [J].

Becker, HF ;

Jerrentrup, A ;

Ploch, T ;

Grote, L ;

Penzel, T ;

Sullivan, CE ;

Peter, JH .

CIRCULATION, 2003, 107 (01) :68-73

[10] NOCTURNAL DYSPNEA AND ATRIAL-FIBRILLATION PREDICT CHEYNE-STOKES RESPIRATIONS IN PATIENTS WITH CONGESTIVE-HEART-FAILURE [J].

BLACKSHEAR, JL ;

KAPLAN, J ;

THOMPSON, RC ;

SAFFORD, RE ;

ATKINSON, EJ .

ARCHIVES OF INTERNAL MEDICINE, 1995, 155 (12) :1297-1302

← 1 2 3 4 5 6 7 8 9 10 →