Spinal cord injury (SCI) affects thousands of people each year and there are no treatments that dramatically improve clinical outcome. Canine intervertebral disc herniation is a naturally-occurring SCI that has similarities to human injury and can be used as a translational model for evaluating therapeutic interventions. Here, we characterized cerebrospinal fluid (CSF) acute phase proteins (APPs) that have altered expression across a spectrum of neurological disorders, using this canine model system. The concentrations of C-reactive protein (CRP), haptoglobin (Hp), alpha-1-glycoprotein, and serum amyloid A were determined in the CSF of 42 acutely injured dogs, compared with 21 healthy control dogs. Concentrations of APPs also were examined with respect to initial injury severity and motor outcome 42 d post-injury. Hp concentration was significantly higher (p < 0.0001) in the CSF of affected dogs, compared with healthy control dogs. Additionally, the concentrations of CRP and Hp were significantly (p = 0.0001 and p = 0.0079, respectively) and positively associated with CSF total protein concentration. The concentrations of CRP and Hp were significantly higher (p = 0.0071 and p = 0.0197, respectively) in dogs with severe injury, compared with those with mild-to-moderate SCI, but there was no significant correlation between assessed CSF APP concentrations and 42 d motor outcome. This study demonstrated that CSF APPs were dysregulated in dogs with naturally-occurring SCI and could be used as markers for SCI severity. As Hp was increased following severe SCI and is neuroprotective across a number of model systems, it may represent a viable therapeutic target.
机构:Univ Calif Irvine, Gillespie Neurosci Res Facil 1105, Irvine, CA 92697 USA
Beck, Kevin D.
;
Nguyen, Hal X.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Gillespie Neurosci Res Facil 1105, Irvine, CA 92697 USA
Univ Calif Irvine, Sue & Bill Gross Stem Cell Res Ctr, Irvine, CA 92697 USAUniv Calif Irvine, Gillespie Neurosci Res Facil 1105, Irvine, CA 92697 USA
Nguyen, Hal X.
;
Galvan, Manuel D.
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif Irvine, Gillespie Neurosci Res Facil 1105, Irvine, CA 92697 USA
Galvan, Manuel D.
;
Salazar, Desiree L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Sue & Bill Gross Stem Cell Res Ctr, Irvine, CA 92697 USAUniv Calif Irvine, Gillespie Neurosci Res Facil 1105, Irvine, CA 92697 USA
Salazar, Desiree L.
;
Woodruff, Trent M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, AustraliaUniv Calif Irvine, Gillespie Neurosci Res Facil 1105, Irvine, CA 92697 USA
Woodruff, Trent M.
;
Anderson, Aileen J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Gillespie Neurosci Res Facil 1105, Irvine, CA 92697 USA
Univ Calif Irvine, Reeve Irvine Res Ctr, Irvine, CA 92697 USAUniv Calif Irvine, Gillespie Neurosci Res Facil 1105, Irvine, CA 92697 USA
机构:
Univ Vet Med Hannover, Dept Small Anim Med & Surg, D-30559 Hannover, GermanyUniv Vet Med Hannover, Dept Small Anim Med & Surg, D-30559 Hannover, Germany
Boekhoff, Theda Marie Anne
;
Ensinger, Eva-Maria
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vet Med Hannover, Dept Small Anim Med & Surg, D-30559 Hannover, GermanyUniv Vet Med Hannover, Dept Small Anim Med & Surg, D-30559 Hannover, Germany
Ensinger, Eva-Maria
;
Carlson, Regina
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vet Med Hannover, Dept Small Anim Med & Surg, D-30559 Hannover, GermanyUniv Vet Med Hannover, Dept Small Anim Med & Surg, D-30559 Hannover, Germany
Carlson, Regina
;
Bock, Patricia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vet Med Hannover, Dept Pathol, D-30559 Hannover, GermanyUniv Vet Med Hannover, Dept Small Anim Med & Surg, D-30559 Hannover, Germany
Bock, Patricia
;
Baumgaertner, Wolfgang
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vet Med Hannover, Dept Pathol, D-30559 Hannover, GermanyUniv Vet Med Hannover, Dept Small Anim Med & Surg, D-30559 Hannover, Germany
Baumgaertner, Wolfgang
;
Rohn, Karl
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vet Med Hannover, Inst Biometry Epidemiol & Informat Proc, D-30559 Hannover, GermanyUniv Vet Med Hannover, Dept Small Anim Med & Surg, D-30559 Hannover, Germany
Rohn, Karl
;
Tipold, Andrea
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h-index: 0
机构:
Univ Vet Med Hannover, Dept Small Anim Med & Surg, D-30559 Hannover, GermanyUniv Vet Med Hannover, Dept Small Anim Med & Surg, D-30559 Hannover, Germany
Tipold, Andrea
;
Stein, Veronika Maria
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vet Med Hannover, Dept Small Anim Med & Surg, D-30559 Hannover, GermanyUniv Vet Med Hannover, Dept Small Anim Med & Surg, D-30559 Hannover, Germany
机构:
Univ Autonoma Barcelona, Fac Vet, Dept Med & Cirurgia Anim, Bellaterra 08193, Barcelona, Spain
Univ Autonoma Barcelona, Fac Vet, Fundacio Hosp Clin Vet, Bellaterra 08193, Barcelona, SpainUniv Autonoma Barcelona, Fac Vet, Dept Med & Cirurgia Anim, Bellaterra 08193, Barcelona, Spain
de la Fuente, C.
;
Monreal, L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Fac Vet, Dept Med & Cirurgia Anim, Bellaterra 08193, Barcelona, SpainUniv Autonoma Barcelona, Fac Vet, Dept Med & Cirurgia Anim, Bellaterra 08193, Barcelona, Spain
Monreal, L.
;
论文数: 引用数:
h-index:
机构:
Ceron, J.
;
Pastor, J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Fac Vet, Dept Med & Cirurgia Anim, Bellaterra 08193, Barcelona, Spain
Univ Autonoma Barcelona, Fac Vet, Fundacio Hosp Clin Vet, Bellaterra 08193, Barcelona, SpainUniv Autonoma Barcelona, Fac Vet, Dept Med & Cirurgia Anim, Bellaterra 08193, Barcelona, Spain
Pastor, J.
;
Viu, J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Fac Vet, Dept Med & Cirurgia Anim, Bellaterra 08193, Barcelona, SpainUniv Autonoma Barcelona, Fac Vet, Dept Med & Cirurgia Anim, Bellaterra 08193, Barcelona, Spain
Viu, J.
;
Anor, S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Fac Vet, Dept Med & Cirurgia Anim, Bellaterra 08193, Barcelona, Spain
Univ Autonoma Barcelona, Fac Vet, Fundacio Hosp Clin Vet, Bellaterra 08193, Barcelona, SpainUniv Autonoma Barcelona, Fac Vet, Dept Med & Cirurgia Anim, Bellaterra 08193, Barcelona, Spain
机构:Univ Calif Irvine, Gillespie Neurosci Res Facil 1105, Irvine, CA 92697 USA
Beck, Kevin D.
;
Nguyen, Hal X.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Gillespie Neurosci Res Facil 1105, Irvine, CA 92697 USA
Univ Calif Irvine, Sue & Bill Gross Stem Cell Res Ctr, Irvine, CA 92697 USAUniv Calif Irvine, Gillespie Neurosci Res Facil 1105, Irvine, CA 92697 USA
Nguyen, Hal X.
;
Galvan, Manuel D.
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif Irvine, Gillespie Neurosci Res Facil 1105, Irvine, CA 92697 USA
Galvan, Manuel D.
;
Salazar, Desiree L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Sue & Bill Gross Stem Cell Res Ctr, Irvine, CA 92697 USAUniv Calif Irvine, Gillespie Neurosci Res Facil 1105, Irvine, CA 92697 USA
Salazar, Desiree L.
;
Woodruff, Trent M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, AustraliaUniv Calif Irvine, Gillespie Neurosci Res Facil 1105, Irvine, CA 92697 USA
Woodruff, Trent M.
;
Anderson, Aileen J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Gillespie Neurosci Res Facil 1105, Irvine, CA 92697 USA
Univ Calif Irvine, Reeve Irvine Res Ctr, Irvine, CA 92697 USAUniv Calif Irvine, Gillespie Neurosci Res Facil 1105, Irvine, CA 92697 USA
机构:
Univ Vet Med Hannover, Dept Small Anim Med & Surg, D-30559 Hannover, GermanyUniv Vet Med Hannover, Dept Small Anim Med & Surg, D-30559 Hannover, Germany
Boekhoff, Theda Marie Anne
;
Ensinger, Eva-Maria
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vet Med Hannover, Dept Small Anim Med & Surg, D-30559 Hannover, GermanyUniv Vet Med Hannover, Dept Small Anim Med & Surg, D-30559 Hannover, Germany
Ensinger, Eva-Maria
;
Carlson, Regina
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vet Med Hannover, Dept Small Anim Med & Surg, D-30559 Hannover, GermanyUniv Vet Med Hannover, Dept Small Anim Med & Surg, D-30559 Hannover, Germany
Carlson, Regina
;
Bock, Patricia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vet Med Hannover, Dept Pathol, D-30559 Hannover, GermanyUniv Vet Med Hannover, Dept Small Anim Med & Surg, D-30559 Hannover, Germany
Bock, Patricia
;
Baumgaertner, Wolfgang
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vet Med Hannover, Dept Pathol, D-30559 Hannover, GermanyUniv Vet Med Hannover, Dept Small Anim Med & Surg, D-30559 Hannover, Germany
Baumgaertner, Wolfgang
;
Rohn, Karl
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vet Med Hannover, Inst Biometry Epidemiol & Informat Proc, D-30559 Hannover, GermanyUniv Vet Med Hannover, Dept Small Anim Med & Surg, D-30559 Hannover, Germany
Rohn, Karl
;
Tipold, Andrea
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vet Med Hannover, Dept Small Anim Med & Surg, D-30559 Hannover, GermanyUniv Vet Med Hannover, Dept Small Anim Med & Surg, D-30559 Hannover, Germany
Tipold, Andrea
;
Stein, Veronika Maria
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vet Med Hannover, Dept Small Anim Med & Surg, D-30559 Hannover, GermanyUniv Vet Med Hannover, Dept Small Anim Med & Surg, D-30559 Hannover, Germany
机构:
Univ Autonoma Barcelona, Fac Vet, Dept Med & Cirurgia Anim, Bellaterra 08193, Barcelona, Spain
Univ Autonoma Barcelona, Fac Vet, Fundacio Hosp Clin Vet, Bellaterra 08193, Barcelona, SpainUniv Autonoma Barcelona, Fac Vet, Dept Med & Cirurgia Anim, Bellaterra 08193, Barcelona, Spain
de la Fuente, C.
;
Monreal, L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Fac Vet, Dept Med & Cirurgia Anim, Bellaterra 08193, Barcelona, SpainUniv Autonoma Barcelona, Fac Vet, Dept Med & Cirurgia Anim, Bellaterra 08193, Barcelona, Spain
Monreal, L.
;
论文数: 引用数:
h-index:
机构:
Ceron, J.
;
Pastor, J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Fac Vet, Dept Med & Cirurgia Anim, Bellaterra 08193, Barcelona, Spain
Univ Autonoma Barcelona, Fac Vet, Fundacio Hosp Clin Vet, Bellaterra 08193, Barcelona, SpainUniv Autonoma Barcelona, Fac Vet, Dept Med & Cirurgia Anim, Bellaterra 08193, Barcelona, Spain
Pastor, J.
;
Viu, J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Fac Vet, Dept Med & Cirurgia Anim, Bellaterra 08193, Barcelona, SpainUniv Autonoma Barcelona, Fac Vet, Dept Med & Cirurgia Anim, Bellaterra 08193, Barcelona, Spain
Viu, J.
;
Anor, S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Barcelona, Fac Vet, Dept Med & Cirurgia Anim, Bellaterra 08193, Barcelona, Spain
Univ Autonoma Barcelona, Fac Vet, Fundacio Hosp Clin Vet, Bellaterra 08193, Barcelona, SpainUniv Autonoma Barcelona, Fac Vet, Dept Med & Cirurgia Anim, Bellaterra 08193, Barcelona, Spain