Insertion/deletion polymorphism of the ACE gene is associated with type 2 diabetes

被引：56
作者：
Feng, Y
Niu, TH
Xu, X
Chen, CZ
Li, QF
Qian, RL
Wang, GY
Xu, XP
机构：
[1] Harvard Univ, Sch Publ Hlth, Program Populat Genet, Boston, MA 02115 USA
[2] Beijing Univ, Affiliated Hosp 3, Div Endocrinol, Beijing, Peoples R China
[3] Beijing Univ, Ctr Ecogenet & Reprod Hlth, Beijing, Peoples R China
[4] Beijing Univ, Affiliated Hosp 1, Div Endocrinol, Beijing, Peoples R China
来源：
DIABETES | 2002年 / 51卷 / 06期
关键词：
D O I：
10.2337/diabetes.51.6.1986
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In an attempt to examine the role of an ACE gene insertion/deletion (I/D) polymorphism in type 2 diabetes, we conducted a case-control association study among 132 couple-pairs from northern China. The genotype frequencies for II, ID, and DD were 39.8, 39.8, and 20.3%, respectively, in the case group and 44.8, 44.8, and 10.4% in the control group. The DD frequency was significantly higher in the case group than in the control group (chi(1)(2) = 4.77, P = 0.03), suggesting that the DD genotype is associated with an increased susceptibility to type 2 diabetes in our study population.
引用
收藏
页码：1986 / 1988
页数：3
相关论文
共 22 条
  • [1] BUFFONE GJ, 1985, CLIN CHEM, V31, P164
  • [2] Insertion/deletion polymorphism of the angiotensin I-converting enzyme gene in patients with hypertension, non-insulin-dependent diabetes mellitus, and coronary heart disease in Taiwan
    Chuang, LM
    Chiu, KC
    Chiang, FT
    Lee, KC
    Wu, HP
    Lin, BJ
    Tai, TY
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 1997, 46 (10): : 1211 - 1214
  • [3] Cong ND, 1999, P SOC EXP BIOL MED, V220, P46
  • [4] EWENS WJ, 1995, AM J HUM GENET, V57, P455
  • [5] ANGIOTENSIN I-CONVERTING ENZYME GENE POLYMORPHISM IS ASSOCIATED WITH MYOCARDIAL-INFARCTION, BUT NOT WITH RETINOPATHY OR NEPHROPATHY, IN NIDDM
    FUJISAWA, T
    IKEGAMI, H
    SHEN, GQ
    YAMATO, E
    TAKEKAWA, K
    NAKAGAWA, Y
    HAMADA, Y
    UEDA, H
    RAKUGI, H
    HIGAKI, J
    OHISHI, M
    FUJII, K
    FUKUDA, M
    OGIHARA, T
    [J]. DIABETES CARE, 1995, 18 (07) : 983 - 985
  • [6] Meta-analysis of association of insertion/deletion polymorphism of angiotensin I-converting enzyme gene with diabetic nephropathy and retinopathy
    Fujisawa, T
    Ikegami, H
    Kawaguchi, Y
    Hamada, Y
    Ueda, H
    Shintani, M
    Fukuda, M
    Ogihara, T
    [J]. DIABETOLOGIA, 1998, 41 (01) : 47 - 53
  • [7] HARRIS MI, 1999, CURRENT REV DIABETES, P3
  • [8] Increased frequency of angiotensin-converting enzyme DD genotype in patients with type 2 diabetes in Taiwan
    Hsieh, MC
    Lin, SR
    Hsieh, TJ
    Hsu, CH
    Chen, HC
    Shin, SJ
    Tsai, JH
    [J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 2000, 15 (07) : 1008 - 1013
  • [9] HSIEH MC, 1999, J HYPERTENS, V17, P1469
  • [10] Angiotensin-converting enzyme gene polymorphism is associated with coronary heart disease in non-insulin-dependent diabetic patients evaluated for 9 years
    Huang, XH
    Rantalaiho, V
    Wirta, O
    Pasternack, A
    Koivula, T
    Hiltunen, TP
    Nikkari, T
    Lehtimaki, T
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 1998, 47 (10): : 1258 - 1262
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