Insertion/deletion polymorphism of the ACE gene is associated with type 2 diabetes

被引：56

作者：

Feng, Y

Niu, TH

Xu, X

Chen, CZ

Li, QF

Qian, RL

Wang, GY

Xu, XP

机构：

[1] Harvard Univ, Sch Publ Hlth, Program Populat Genet, Boston, MA 02115 USA

[2] Beijing Univ, Affiliated Hosp 3, Div Endocrinol, Beijing, Peoples R China

[3] Beijing Univ, Ctr Ecogenet & Reprod Hlth, Beijing, Peoples R China

[4] Beijing Univ, Affiliated Hosp 1, Div Endocrinol, Beijing, Peoples R China

来源：

DIABETES | 2002年 / 51卷 / 06期

关键词：

D O I：

10.2337/diabetes.51.6.1986

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In an attempt to examine the role of an ACE gene insertion/deletion (I/D) polymorphism in type 2 diabetes, we conducted a case-control association study among 132 couple-pairs from northern China. The genotype frequencies for II, ID, and DD were 39.8, 39.8, and 20.3%, respectively, in the case group and 44.8, 44.8, and 10.4% in the control group. The DD frequency was significantly higher in the case group than in the control group (chi(1)(2) = 4.77, P = 0.03), suggesting that the DD genotype is associated with an increased susceptibility to type 2 diabetes in our study population.

引用

页码：1986 / 1988

页数：3

共 22 条

[1]

BUFFONE GJ, 1985, CLIN CHEM, V31, P164

[2] Insertion/deletion polymorphism of the angiotensin I-converting enzyme gene in patients with hypertension, non-insulin-dependent diabetes mellitus, and coronary heart disease in Taiwan [J].

Chuang, LM ;

Chiu, KC ;

Chiang, FT ;

Lee, KC ;

Wu, HP ;

Lin, BJ ;

Tai, TY .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1997, 46 (10) :1211-1214

[3]

Cong ND, 1999, P SOC EXP BIOL MED, V220, P46

[4]

EWENS WJ, 1995, AM J HUM GENET, V57, P455

[5] ANGIOTENSIN I-CONVERTING ENZYME GENE POLYMORPHISM IS ASSOCIATED WITH MYOCARDIAL-INFARCTION, BUT NOT WITH RETINOPATHY OR NEPHROPATHY, IN NIDDM [J].

FUJISAWA, T ;

IKEGAMI, H ;

SHEN, GQ ;

YAMATO, E ;

TAKEKAWA, K ;

NAKAGAWA, Y ;

HAMADA, Y ;

UEDA, H ;

RAKUGI, H ;

HIGAKI, J ;

OHISHI, M ;

FUJII, K ;

FUKUDA, M ;

OGIHARA, T .

DIABETES CARE, 1995, 18 (07) :983-985

[6] Meta-analysis of association of insertion/deletion polymorphism of angiotensin I-converting enzyme gene with diabetic nephropathy and retinopathy [J].

Fujisawa, T ;

Ikegami, H ;

Kawaguchi, Y ;

Hamada, Y ;

Ueda, H ;

Shintani, M ;

Fukuda, M ;

Ogihara, T .

DIABETOLOGIA, 1998, 41 (01) :47-53

[7]

HARRIS MI, 1999, CURRENT REV DIABETES, P3

[8] Increased frequency of angiotensin-converting enzyme DD genotype in patients with type 2 diabetes in Taiwan [J].

Hsieh, MC ;

Lin, SR ;

Hsieh, TJ ;

Hsu, CH ;

Chen, HC ;

Shin, SJ ;

Tsai, JH .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2000, 15 (07) :1008-1013

[9]

HSIEH MC, 1999, J HYPERTENS, V17, P1469

[10] Angiotensin-converting enzyme gene polymorphism is associated with coronary heart disease in non-insulin-dependent diabetic patients evaluated for 9 years [J].

Huang, XH ;

Rantalaiho, V ;

Wirta, O ;

Pasternack, A ;

Koivula, T ;

Hiltunen, TP ;

Nikkari, T ;

Lehtimaki, T .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1998, 47 (10) :1258-1262

← 1 2 3 →