Bimodal gene expression patterns in breast cancer

被引：27

作者：

Bessarabova, Marina ^{[2
]}

Kirillov, Eugene ^{[2
]}

Shi, Weiwei ^{[1
]}

Bugrim, Andrej ^{[1
]}

Nikolsky, Yuri ^{[1
]}

Nikolskaya, Tatiana ^{[2
]}

机构：

[1] Genego Inc, St Joseph, MI 49085 USA

[2] Russian Acad Sci, Vavilov Inst Gen Genet, Moscow, Russia

来源：

BMC GENOMICS | 2010年 / 11卷

关键词：

MOLECULAR PORTRAITS; MICROARRAY; SIGNATURE; PROFILES; CLASSIFICATION; REPRODUCIBILITY; METAANALYSIS; VALIDATION; ACTIVATION; CARCINOMAS;

D O I：

10.1186/1471-2164-11-S1-S8

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We identified a set of genes with an unexpected bimodal distribution among breast cancer patients in multiple studies. The property of bimodality seems to be common, as these genes were found on multiple microarray platforms and in studies with different end-points and patient cohorts. Bimodal genes tend to cluster into small groups of four to six genes with synchronised expression within the group (but not between the groups), which makes them good candidates for robust conditional descriptors. The groups tend to form concise network modules underlying their function in cancerogenesis of breast neoplasms.

引用

收藏

页数：14

相关论文

共 53 条

[41]

SHI W, 2009, NAT BIOTECH IN PRESS

[42] Repeated observation of breast tumor subtypes in independent gene expression data sets [J].

Sorlie, T ;

Tibshirani, R ;

Parker, J ;

Hastie, T ;

Marron, JS ;

Nobel, A ;

Deng, S ;

Johnsen, H ;

Pesich, R ;

Geisler, S ;

Demeter, J ;

Perou, CM ;

Lonning, PE ;

Brown, PO ;

Borresen-Dale, AL ;

Botstein, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (14) :8418-8423

[43] Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications [J].

Sorlie, T ;

Perou, CM ;

Tibshirani, R ;

Aas, T ;

Geisler, S ;

Johnsen, H ;

Hastie, T ;

Eisen, MB ;

van de Rijn, M ;

Jeffrey, SS ;

Thorsen, T ;

Quist, H ;

Matese, JC ;

Brown, PO ;

Botstein, D ;

Lonning, PE ;

Borresen-Dale, AL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (19) :10869-10874

[44] Meta-analysis of gene expression in mouse preimplantation embryo development [J].

Stanton, JL ;

Green, DPL .

MOLECULAR HUMAN REPRODUCTION, 2001, 7 (06) :545-552

[45] PACK: Profile Analysis using Clustering and Kurtosis to find molecular classifiers in cancer [J].

Teschendorff, Andrew E. ;

Naderi, Ali ;

Barbosa-Morais, Nuno L. ;

Caldas, Carlos .

BIOINFORMATICS, 2006, 22 (18) :2269-2275

[46] Novel markers for differentiation of lobular and ductal invasive breast carcinomas by laser microdissection and microarray analysis [J].

Turashvili, Gulisa ;

Bouchal, Jan ;

Baumforth, Karl ;

Wei, Wenbin ;

Dziechciarkova, Marta ;

Ehrmann, Jiri ;

Klein, Jiri ;

Fridman, Eduard ;

Skarda, Jozef ;

Srovnal, Josef ;

Hajduch, Marian ;

Murray, Paul ;

Kolar, Zdenek .

BMC CANCER, 2007, 7 (1)

[47] Significance analysis of microarrays applied to the ionizing radiation response [J].

Tusher, VG ;

Tibshirani, R ;

Chu, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (09) :5116-5121

[48] Gene expression profiling predicts clinical outcome of breast cancer [J].

van't Veer, LJ ;

Dai, HY ;

van de Vijver, MJ ;

He, YDD ;

Hart, AAM ;

Mao, M ;

Peterse, HL ;

van der Kooy, K ;

Marton, MJ ;

Witteveen, AT ;

Schreiber, GJ ;

Kerkhoven, RM ;

Roberts, C ;

Linsley, PS ;

Bernards, R ;

Friend, SH .

NATURE, 2002, 415 (6871) :530-536

[49] Gene-expression pro-files to predict distant metastasis of lymph-node-negative primary breast cancer [J].

Wang, YX ;

Klijn, JGM ;

Zhang, Y ;

Sieuwerts, A ;

Look, MP ;

Yang, F ;

Talantov, D ;

Timmermans, M ;

Meijer-van Gelder, ME ;

Yu, J ;

Jatkoe, T ;

Berns, EMJJ ;

Atkins, D ;

Foekens, JA .

LANCET, 2005, 365 (9460) :671-679

[50] Molecular portraits and 70-gene prognosis signature are preserved throughout the metastatic process of breast cancer [J].

Weigelt, B ;

Hu, ZY ;

He, XP ;

Livasy, C ;

Carey, LA ;

Ewend, MG ;

Glas, AM ;

Perou, CM ;

van't Veer, LJ .

CANCER RESEARCH, 2005, 65 (20) :9155-9158

← 1 2 3 4 5 6 →