Bimodal gene expression patterns in breast cancer

被引：27

作者：

Bessarabova, Marina ^{[2
]}

Kirillov, Eugene ^{[2
]}

Shi, Weiwei ^{[1
]}

Bugrim, Andrej ^{[1
]}

Nikolsky, Yuri ^{[1
]}

Nikolskaya, Tatiana ^{[2
]}

机构：

[1] Genego Inc, St Joseph, MI 49085 USA

[2] Russian Acad Sci, Vavilov Inst Gen Genet, Moscow, Russia

来源：

BMC GENOMICS | 2010年 / 11卷

关键词：

MOLECULAR PORTRAITS; MICROARRAY; SIGNATURE; PROFILES; CLASSIFICATION; REPRODUCIBILITY; METAANALYSIS; VALIDATION; ACTIVATION; CARCINOMAS;

D O I：

10.1186/1471-2164-11-S1-S8

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We identified a set of genes with an unexpected bimodal distribution among breast cancer patients in multiple studies. The property of bimodality seems to be common, as these genes were found on multiple microarray platforms and in studies with different end-points and patient cohorts. Bimodal genes tend to cluster into small groups of four to six genes with synchronised expression within the group (but not between the groups), which makes them good candidates for robust conditional descriptors. The groups tend to form concise network modules underlying their function in cancerogenesis of breast neoplasms.

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页数：14

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