The interplay between neutrophils, complement, and microthrombi in COVID-19

被引：33

作者：

Zuo, Yu ^{[1
]}

Kanthi, Yogendra ^{[2
]}

Knight, Jason S. ^{[1
]}

Kim, Alfred H. J. ^{[3
]}

机构：

[1] Univ Michigan, Dept Internal Med, Div Rheumatol, Ann Arbor, MI 48109 USA

[2] NHLBI, Div Intramural Res, Bldg 10, Bethesda, MD 20892 USA

[3] Washington Univ, Sch Med, Dept Med, Div Rheumatol, St Louis, MO 63110 USA

来源：

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY | 2021年 / 35卷 / 01期

关键词：

COVID-19; SARS-CoV-2; Neutrophil extracellular traps; NETs; Complement; Innate immunity; Thrombotic microangiopathy; EXTRACELLULAR TRAP RELEASE; THROMBOTIC MICROANGIOPATHY; ENDOTHELIAL INJURY; ACTIVATION; INSIGHTS; COAGULATION; ECULIZUMAB; INDUCTION; RESPONSES; DISEASE;

D O I：

10.1016/j.berh.2021.101661

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

As of the end of 2020, coronavirus disease 2019 (COVID-19) remains a global healthcare challenge with alarming death tolls. In the absence of targeted therapies, supportive care continues to be the mainstay of treatment. The hallmark of severe COVID-19 is a thromboinflammatory storm driven by innate immune responses. This manifests clinically as acute respiratory distress syndrome, and in some patients, widespread thrombotic microangiopathy. Neutrophils and complement are key players in the innate immune system, and their role in perpetuating fatal severe COVID-19 continues to receive increasing attention. Here, we review the interplay between neutrophils, neutrophil extracellular traps, and complement in COVID-19 immunopathology, and highlight potential therapeutic strategies to combat these pathways. (C) 2021 Elsevier Ltd. All rights reserved.

引用

页数：12

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