Serotype and antibiotic resistance of isolates from patients with invasive pneumococcal disease in Japan

被引：60

作者：

Chiba, N.

Morozumi, M.

Sunaoshi, K.

Takahashi, S. ^{[2
]}

Takano, M. ^{[3
]}

Komori, T. ^{[4
]}

Sunakawa, K. ^{[5
]}

Ubukata, K. ^{[1
]}

机构：

[1] Kitasato Univ, Grad Sch Infect Control Sci, Lab Mol Epidemiol Infect Agents, Minato Ku, Tokyo 1088641, Japan

[2] Sapporo City Gen Hosp, Lab Clin Microbiol, Sapporo, Hokkaido, Japan

[3] Niigata Univ, Med & Dent Hosp, Lab Clin Bacteriol, Niigata, Japan

[4] Kyoto Prefectural Univ Med, Dept Clin Lab, Kyoto, Japan

[5] Kitasato Univ, Infect Dis Lab, Grad Sch Infect Control Sci, Tokyo, Japan

来源：

EPIDEMIOLOGY AND INFECTION | 2010年 / 138卷 / 01期

关键词：

Antibiotic resistance; molecular epidemiology; Streptococcus pneumoniae (pneumococcus); surveillance; vaccines; PENICILLIN-BINDING PROTEIN; STREPTOCOCCUS-PNEUMONIAE; ANTIMICROBIAL RESISTANCE; SUSCEPTIBILITY; VACCINE; GENES; SURVEILLANCE; POPULATION; MENINGITIS; AUTOLYSIN;

D O I：

10.1017/S0950268809990239

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Invasive pneumococcal disease (IPD) is of concern in Japan, where the heptavalent pneumococcal conjugate vaccine (PCV7) is unavailable. We determined serotypes, genotypes indicating beta-lactam resistance, and antibiotic susceptibilities of 496 isolates from normally sterile sites in patients (193 children, 303 adults) from 186 institutions between August 2006 and July 2007. Disease presentations included sepsis (46.2%), pneumonia (31.5%), and meningitis (17.5%). Mortality was 1.4% in children and 22.1% in adults, many of whom had underlying diseases. In children, serotype 6B (22.5%) was followed by 19F (14.1%), and 14 (13.1%); potential coverages of PCV7 and PCV13 were 75.4% and 93.7%, respectively. In adults, serotype 12F (14.3%) was followed by 3 (11.3%), and 6B (10.3%); 23-valent polysaccharide vaccine (PPV23) coverage was 85.4%. Most serotype 12F strains were gPISP, with pbp2b gene alteration; carbapenem had an excellent MIC90. PCV7 is recommended for children and PPV23 for adults to increase prevention against IPD.

引用

页码：61 / 68

页数：8

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