Three-Component Condensation of 4-Imino-1-Phenylimidazolidin-2-One with Aldehydes and Meldrum's Acid: Synthesis of Imidazo[4,5-b]Pyridine-2,5(4H,6H)-Diones and 5-Substituted 1-Phenylhydantoins

被引：3

作者：

Krylov, Constantine S. ^{[1
]}

Komogortsev, Andrey N. ^{[1
]}

Lichitsky, Boris V. ^{[1
]}

Fakhrutdinov, Artem N. ^{[1
]}

Dudinov, Arkady A. ^{[1
]}

Krayushkin, Mikhail M. ^{[1
]}

机构：

[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, 47 Leninsky Ave, Moscow 119991, Russia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2019年 / 55卷 / 09期

关键词：

aldehydes; imidazo[4,5-b]pyridine-2,5(4H,6H)-diones; 4-imino-1-phenylimidazolidin-2-one; Meldrum's acid; 5-substituted; 1-phenylhydantoins; three-component condensation; MALIGNANT HYPERTHERMIA; HYDANTOINS; DANTROLENE; MUSCLE;

D O I：

10.1007/s10593-019-02548-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient method for the synthesis of previously unknown imidazo[4,5-b]pyridine-2,5(4H,6H)-diones has been developed, based on a three-component condensation of 4-imino-1-phenylimidazolidin-2-one with aldehydes and Meldrum's acid. The possibility of accessing 5-substituted 1-phenylhydantoins based on the acid hydrolysis of imidazo[4,5-b]pyridine-2,5(4H,6H)-diones was shown.

引用

页码：851 / 855

页数：5

共 24 条

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