Three-Component Condensation of 4-Imino-1-Phenylimidazolidin-2-One with Aldehydes and Meldrum's Acid: Synthesis of Imidazo[4,5-b]Pyridine-2,5(4H,6H)-Diones and 5-Substituted 1-Phenylhydantoins

被引：3
作者：
Krylov, Constantine S. [1 ]
Komogortsev, Andrey N. [1 ]
Lichitsky, Boris V. [1 ]
Fakhrutdinov, Artem N. [1 ]
Dudinov, Arkady A. [1 ]
Krayushkin, Mikhail M. [1 ]
机构：
[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, 47 Leninsky Ave, Moscow 119991, Russia
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2019年 / 55卷 / 09期
关键词：
aldehydes; imidazo[4,5-b]pyridine-2,5(4H,6H)-diones; 4-imino-1-phenylimidazolidin-2-one; Meldrum's acid; 5-substituted; 1-phenylhydantoins; three-component condensation; MALIGNANT HYPERTHERMIA; HYDANTOINS; DANTROLENE; MUSCLE;
D O I：
10.1007/s10593-019-02548-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient method for the synthesis of previously unknown imidazo[4,5-b]pyridine-2,5(4H,6H)-diones has been developed, based on a three-component condensation of 4-imino-1-phenylimidazolidin-2-one with aldehydes and Meldrum's acid. The possibility of accessing 5-substituted 1-phenylhydantoins based on the acid hydrolysis of imidazo[4,5-b]pyridine-2,5(4H,6H)-diones was shown.
引用
收藏
页码：851 / 855
页数：5
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