Fox-1 family of RNA-binding proteins

被引：151
作者：
Kuroyanagi, Hidehito [1 ,2 ,3 ]
机构：
[1] Tokyo Med & Dent Univ, Grad Sch Biomed Sci, Gene Express Lab, Tokyo 1138510, Japan
[2] Tokyo Med & Dent Univ, Med Res Inst, Dept Funct Genom, Tokyo 1138510, Japan
[3] Japan Sci & Technol Agcy JST, Precursory Res Embryon Sci & Technol PRESTO, Kawaguchi, Saitama 3320012, Japan
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2009年 / 66卷 / 24期
关键词：
Alternative splicing; Fox-1; UGCAUG; Tissue-specificity; RNA recognition motif; CLIP; Splicing regulatory network; PRE-MESSENGER-RNA; ALTERNATIVE SPLICING EVENTS; X-CHROMOSOME; REGULATORY ELEMENTS; COMPLEX-FORMATION; SEX MYOBLASTS; EXPRESSION; INTRON; RECOGNITION; MECHANISMS;
D O I：
10.1007/s00018-009-0120-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Fox-1 family of RNA-binding proteins are evolutionarily conserved regulators of tissue-specific alternative splicing in metazoans. The Fox-1 family specifically recognizes the (U)GCAUG stretch in regulated exons or in flanking introns, and either promotes or represses target exons. Recent unbiased bioinformatics analyses of alternatively spliced exons and comparison of various vertebrate genomes identified the (U)GCAUG stretch as a highly conserved and widely distributed element enriched in intronic regions surrounding exons with altered inclusion in muscle, heart, and brain, consistent with specific expression of Fox-1 and Fox-2 in these tissues. Global identification of Fox-2 target RNAs in living cells revealed that many of the Fox-2 target genes themselves encode splicing regulators. Further systematic elucidation of target genes of the Fox-1 family and other splicing regulators in various tissues will lead to a comprehensive understanding of splicing regulatory networks.
引用
收藏
页码：3895 / 3907
页数：13
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