Synthesis, DNA-binding, photocleavage, cytotoxicity and antioxidant activity of ruthenium (II) polypyridyl complexes

被引：102

作者：

Liu, Yun-Jun ^{[1
]}

Zeng, Cheng-Hui ^{[1
]}

Huang, Hong-Liang ^{[2
]}

He, Li-Xin ^{[1
]}

Wu, Fu-Hai ^{[3
]}

机构：

[1] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China

[2] Guangdong Pharmaceut Univ, Sch Life Sci & Biopharmaceut, Guangzhou 510006, Guangdong, Peoples R China

[3] Guangdong Pharmaceut Univ, Sch Publ Hlth, Guangzhou 510006, Guangdong, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 02期

关键词：

Ruthenium complexes; DNA-binding; Cytotoxicity; Antioxidant activity; DEOXYRIBONUCLEIC-ACID; TOPOISOMERASE-II; NUCLEIC-ACIDS; LIGAND; TRIS(PHENANTHROLINE)RUTHENIUM(II); 2,2-BIPYRIDINE; COBALT(III); CLEAVAGE; SERIES;

D O I：

10.1016/j.ejmech.2009.10.043

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new ligands maip (1a), paip (1b) with their ruthenium (II) complexes [Ru(bpy)(2)(maip)](ClO(4))(2) (2a) and [Ru(bpy)(2)(paip)](ClO(4))(2) (2b) have been synthesized and characterized. The results show that complexes 2a and 2b interact with DNA through intercalative mode. The cytotoxicity of these compounds has been evaluated by MTT assay. The experiments on antioxidant activity show that these compounds exhibit good antioxidant activity against hydroxyl radical (OH(center dot)). Crown Copyright (C) 2009 Published by Elsevier Masson SAS. All rights reserved.

引用

页码：564 / 571

页数：8

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