Specific Recognition of DNA by Small Molecules

被引：35

作者：

Du, Y. H. ^{[1
]}

Huang, J. ^{[1
]}

Weng, X. C. ^{[1
]}

Zhou, X. ^{[1
]}

机构：

[1] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China

来源：

CURRENT MEDICINAL CHEMISTRY | 2010年 / 17卷 / 02期

关键词：

DNA specific recognition; small molecules; interaction; G-QUADRUPLEX DNA; SEQUENCE-SPECIFIC RECOGNITION; GUANINE-GUANINE MISMATCHES; MINOR-GROOVE BINDERS; HUMAN TELOMERIC DNA; DOUBLE-HELICAL DNA; CRYSTAL-STRUCTURE; DRUG-BINDING; IN-VITRO; MACROCYCLIC HEXAOXAZOLES;

D O I：

10.2174/092986710790112648

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA exhibits many attractive features in the development of drug design and disease treatment, and there are some successful events for drugs targeting to DNA in clinic use. Nowadays, the specific recognition of DNA by small molecules is the crucial factor of the sustainable development of DNA-target drugs, for the serious side-effects of existing drugs. In this review, we discussed the current efforts of DNA-drug specific interaction that concerned with various DNA recognition models, such as abasic, mismatch or bulge site recognition, specific sequence recognition, and secondary structure recognition. Some compounds are found to show remarkable potential to be ideal drug.

引用

页码：173 / 189

页数：17

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