Expression of the multidrug resistance gene in human prostate cancer

被引：40

作者：

Bhangal, G ^{[1
]}

Halford, S ^{[1
]}

Wang, J ^{[1
]}

Roylance, R ^{[1
]}

Shah, R ^{[1
]}

Waxman, J ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Oncol, London W12 0NN, England

来源：

UROLOGIC ONCOLOGY | 2000年 / 5卷 / 03期

关键词：

prostate cancer; P-glycoprotein; drug resistance; immunocytochemistry;

D O I：

10.1016/S1078-1439(99)00055-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Prostate cancer has become the most common cancer in males and the second most common cause of male cancer death in England and Wales. Death rates have doubled over the last 20 years. Prostate cancer is characterized by a high initial response rate to hormonal therapy. Drug-resistance is a significant cause of relapse in cancer. The multidrug resistance genes (MDR) encode resistance to a diverse family of cytotoxic chemotherapy agents. There are four known MDR genes, two of which are present in humans. MDR1 encodes for P-glycoprotein, a 170-kDa transmembrane calcium-dependent efflux pump. We examined P-glycoprotein expression by immunocytochemistry in 96 patients with prostate cancer and 20 patients with benign prostatic hypertrophy. A direct correlate mas found between tumor grade, stage, and prostate specific antigen levels, indicating the possible significance of this protein in recurrent prostate cancer. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：118 / 121

页数：4

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