Marked Hypertriglyceridemia in a Patient with type 2 Diabetes Receiving SGLT2 Inhibitors

被引：0

作者：

Senoo, Mayumi ^{[1
]}

Tone, Atsuhito ^{[1
]}

Imai, Yusuke ^{[1
]}

Watanabe, Satoko ^{[1
]}

Kaneto, Mitsuhiro ^{[1
]}

Shimomura, Yasuyuki ^{[1
]}

Teshigawara, Sanae ^{[1
]}

Nakatou, Tatsuaki ^{[1
]}

机构：

[1] Okayama Saiseikai Gen Hosp, Diabet Ctr, Dept Internal Med, Okayama 7008511, Japan

来源：

ACTA MEDICA OKAYAMA | 2021年 / 75卷 / 01期

关键词：

sodium glucose cotransporter 2 inhibitor; dyslipidemia; hypertriglyceridemia; type 2 diabetes mellitus; FREE FATTY-ACIDS; INSULIN-RESISTANCE; ADIPOSE-TISSUE; SAFETY;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A 43-year-old male with type 2 diabetes, under treatment with 5 mg/day of dapagliflozin, was referred to our hospital with upper left abdominal pain and marked hypertriglyceridemia (triglycerides [TGs], 5,960 mg/dl). He was also on a low-carbohydrate diet that promoted ketosis under sodium glucose cotransporter 2 (SGLT2) inhibitor administration. Polyacrylamide gel electrophoresis revealed a remarkable increase in very-low-density lipoprotein, a TG-rich lipoprotein particle synthesized in the liver using free fatty acids derived from adipose tissue. Although SGLT2 inhibitors generally improve the lipid profile, under certain conditions such as a low-carbohydrate diet, they may adversely exacerbate the lipid profile via ketosis.

引用

页码：103 / 107

页数：5

共 17 条

[1] Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes-2020 [J].

不详 .

DIABETES CARE, 2020, 43 :S98-S110

[2] Lipid and lipoprotein dysregulation in insulin resistant states [J].

Avramoglu, Rita Kohen ;

Basciano, Heather ;

Adeli, Khosrow .

CLINICA CHIMICA ACTA, 2006, 368 (1-2) :1-19

[3] Pathogenesis of Lipid Disorders in Insulin Resistance: a Brief Review [J].

Bjornstad, Petter ;

Eckel, Robert H. .

CURRENT DIABETES REPORTS, 2018, 18 (12)

[4] 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD [J].

Cosentino, Francesco ;

Grant, Peter J. ;

Aboyans, Victor ;

Bailey, Clifford J. ;

Ceriello, Antonio ;

Delgado, Victoria ;

Federici, Massimo ;

Filippatos, Gerasimos ;

Grobbee, Diederick E. ;

Hansen, Tina Birgitte ;

Huikuri, Heikki, V ;

Johansson, Isabelle ;

Juni, Peter ;

Lettino, Maddalena ;

Marx, Nikolaus ;

Mellbin, Linda G. ;

Ostgren, Carl J. ;

Rocca, Bianca ;

Roffi, Marco ;

Sattar, Naveed ;

Seferovic, Petar M. ;

Sousa-Uva, Miguel ;

Valensi, Paul ;

Wheeler, David C. ;

Piepoli, Massimo Francesco ;

Birkeland, Kare, I ;

Adamopoulos, Stamatis ;

Ajjan, Ramzi ;

Avogaro, Angelo ;

Baigent, Colin ;

Brodmann, Marianne ;

Bueno, Hector ;

Ceconi, Claudio ;

Chioncel, Ovidiu ;

Coats, Andrew ;

Collet, Jean-Philippe ;

Collins, Peter ;

Cosyns, Bernard ;

Di Mario, Carlo ;

Fisher, Miles ;

Fitzsimons, Donna ;

Halvorsen, Sigrun ;

Hansen, Dominique ;

Hoes, Arno ;

Holt, Richard I. G. ;

Home, Philip ;

Katus, Hugo A. ;

Khunti, Kamlesh ;

Komajda, Michel ;

Lambrinou, Ekaterini .

EUROPEAN HEART JOURNAL, 2020, 41 (02) :255-323

[5] Adipose tissue and the insulin resistance syndrome [J].

Frayn, KN .

PROCEEDINGS OF THE NUTRITION SOCIETY, 2001, 60 (03) :375-380

[6] Regulation of plasma triglycerides in insulin resistance and diabetes [J].

Ginsberg, HN ;

Zhang, YL ;

Hernandez-Ono, A .

ARCHIVES OF MEDICAL RESEARCH, 2005, 36 (03) :232-240

[7] Influence of plasma free fatty acids on lipoprotein synthesis and diabetic dyslipidemia [J].

Julius, U .

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 2003, 111 (05) :246-250

[8] Efficacy and safety of dapagliflozin as a monotherapy for type 2 diabetes mellitus in Japanese patients with inadequate glycaemic control: a phase II multicentre, randomized, double-blind, placebo-controlled trial [J].

Kaku, K. ;

Inoue, S. ;

Matsuoka, O. ;

Kiyosue, A. ;

Azuma, H. ;

Hayashi, N. ;

Tokudome, T. ;

Langkilde, A. M. ;

Parikh, S. .

DIABETES OBESITY & METABOLISM, 2013, 15 (05) :432-440

[9] INTERACTION BETWEEN FREE FATTY-ACIDS AND INSULIN IN THE ACUTE CONTROL OF VERY-LOW-DENSITY LIPOPROTEIN PRODUCTION IN HUMANS [J].

LEWIS, GF ;

UFFELMAN, KD ;

SZETO, LW ;

WELLER, B ;

STEINER, G .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 95 (01) :158-166

[10] SGLT2 inhibitors: their potential reduction in blood pressure [J].

Maliha, George ;

Townsend, Raymond R. .

JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION, 2015, 9 (01) :48-53

← 1 2 →