Neurochemical studies with the novel anticonvulsant levetiracetam in mouse brain

被引：64

作者：

Sills, GJ ^{[1
]}

Leach, JP ^{[1
]}

Fraser, CM ^{[1
]}

Forrest, G ^{[1
]}

Patsalos, PN ^{[1
]}

Brodie, MJ ^{[1
]}

机构：

[1] NATL HOSP,INST NEUROL,LONDON WC1N 3BG,ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1997年 / 325卷 / 01期

关键词：

levetiracetam; GABA (gamma-aminobutyric acid); anti-epileptic drug; epilepsy;

D O I：

10.1016/S0014-2999(97)00105-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Levetiracetam is a novel antiepileptic agent with a wide spectrum of activity against experimental and clinical seizures. The mechanism of its anticonvulsant action remains to be determined. We have investigated the effects of levetiracetam on several gamma-aminobutyric acid (GABA)-related neurochemical parameters in mouse brain. Adult male mice were randomised into two groups and administered levetiracetam (0-300 mg/kg) intraperitoneally either as a single dose or twice daily for 5 days. Four hours after the final dose, animals were killed and their brains removed. Brain tissues were analysed for concentrations of GABA, glutamate and glutamine and for the activities of GABA-transaminase and glutamic acid decarboxylase. Single dose and repeated levetiracetam treatments were without effect on all of the parameters investigated. The anticonvulsant action of levetiracetam is unlikely to be mediated via an action on the GABAergic system. (C) 1997 Elsevier Science B.V.

引用

页码：35 / 40

页数：6

共 22 条

[1]

COULTER DA, 1995, EPILEPSIA, V36, pS40

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