Characterization of estrogen receptors alpha and beta in uterine leiomyoma cells

被引：24
作者：
Valladares, Francisco
Frias, Ignacio
Baez, Delia
Garcia, Candelaria
Lopez, Francisco J.
Fraser, James D.
Rodriguez, Yurena
Reyes, Ricardo
Diaz-Flores, Lucio
Bello, Aixa R.
机构：
[1] Univ La Laguna, Fac Biol, Area Biol Celular, Tenerife 38071, Canary Islands, Spain
[2] Univ La Laguna, Dept Bioquim & Biol Mol, Tenerife 38071, Spain
[3] Univ La Laguna, Fac Med, Dept Obstet & Ginecol, Tenerife 38071, Spain
[4] Univ La Laguna, Dept Anat Anat Patol & Histol, Tenerife 38071, Spain
[5] Ligand Pharmaceut Inc, Dept Pharmacol, San Diego, CA USA
[6] UI Hosp Univ Ntra Sra Candelaria, Inst Canario Invest Canc, RTICCC, Tenerife, Spain
来源：
FERTILITY AND STERILITY | 2006年 / 86卷 / 06期
关键词：
leiomyoma; estrogen receptors; premenopause; postmenopause; connective cells; muscle cells;
D O I：
10.1016/j.fertnstert.2006.05.047
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: Cellular and subcellular localization of estrogen receptor alpha (ER alpha) and estrogen receptor beta (ER beta) in uterine leiomyomas. Design: Retrospective study. Setting: University of La Laguna (ULL) and Canary University Hospital (HUC). Patient(s): Premenopausal and postmenopausal women with uterine leiomyomas. Intervention(s): Hysterectomy and myomectomy. Result(s): Estrogen receptor alpha was only present in smooth muscle cells with variation in the subcellular location in different leiomyomas. Estrogen receptor beta was widely distributed in smooth muscle, endothelial, and connective tissue cells with nuclear location in all cases studied; variations were only found in the muscle cells for this receptor. Conclusion(s): Estrogens operate in leiomyoma smooth muscle cells through different receptors, alpha and beta. However they only act through the ER beta in endothelial and connective cells.
引用
收藏
页码：1736 / 1743
页数：8
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