NeuroExercise: The Effect of a 12-Month Exercise Intervention on Cognition in Mild Cognitive Impairment-A Multicenter Randomized Controlled Trial

被引：18

作者：

Stuckenschneider, Tim ^{[1
,2
]}

Sanders, Marit L. ^{[3
,4
]}

Devenney, Kate E. ^{[5
]}

Aaronson, Justine A. ^{[4
,6
]}

Abeln, Vera ^{[1
]}

Claassen, Jurgen A. H. R. ^{[3
,4
]}

Guinan, Emer ^{[5
]}

Lawlor, Brian ^{[7
,8
]}

Meeusen, Romain ^{[9
]}

Montag, Christian ^{[10
]}

Olde Rikkert, Marcel G. M. ^{[3
,4
]}

Polidori, M. Cristina ^{[11
,12
,13
]}

Reuter, Martin ^{[14
,15
]}

Schulz, Ralf-Joachim ^{[16
]}

Vogt, Tobias ^{[17
,18
]}

Weber, Bernd ^{[14
]}

Kessels, Roy P. C. ^{[4
,6
]}

Schneider, Stefan ^{[1
,2
]}

机构：

[1] German Sport Univ Cologne, Inst Movement & Neurosci, Cologne, Germany

[2] Univ Sunshine Coast, Sch Hlth & Sport Sci, VasoAct Res Grp, Maroochydore, Qld, Australia

[3] Radboud Univ Nijmegen Med Ctr, Dept Geriatr Med, Radboudumc Alzheimer Ctr, Nijmegen, Netherlands

[4] Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands

[5] Trinity Coll Dublin, Discipline Physiotherapy, Dublin, Ireland

[6] Radboud Univ Nijmegen Med Ctr, Dept Med Psychol, Nijmegen, Netherlands

[7] Trinity Coll Dublin, Mercers Inst Successful Aging, St Jamess Hosp, Dublin, Ireland

[8] Trinity Coll Dublin, Global Brain Hlth Inst, Dublin, Ireland

[9] Vrije Univ Brussel, Dept Human Physiol & Sports Med, Brussels, Belgium

[10] Ulm Univ, Inst Psychol & Educ, Dept Mol Psychol, Ulm, Germany

[11] Univ Cologne, Aging Clin Res, Dept Internal Med 2, Cologne, Germany

[12] Univ Cologne, Ctr Mol Med Cologne, Fac Med, Cologne, Germany

[13] Univ Cologne, Univ Hosp Cologne, Cologne, Germany

[14] Univ Bonn, Ctr Econ & Neurosci, Bonn, Germany

[15] Univ Bonn, Dept Psychol, Bonn, Germany

[16] Univ Cologne, Dept Geriatr, Fac Med, Cologne, Germany

[17] German Sport Univ Cologne, Inst Profess Sport Educ & Sport Qualificat, Cologne, Germany

[18] Waseda Univ, Fac Sport Sci, Tokorozawa, Saitama, Japan

来源：

FRONTIERS IN AGING NEUROSCIENCE | 2021年 / 12卷

关键词：

Alzheimer's disease; non-pharmacological treatment; aerobic exercise; cognition; quality of life; ALZHEIMERS ASSOCIATION WORKGROUPS; CARDIORESPIRATORY FITNESS; PHYSICAL-EXERCISE; OLDER-ADULTS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; DEMENTIA; DISEASE; OUTCOMES; RECOMMENDATIONS;

D O I：

10.3389/fnagi.2020.621947

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Exercise intervention studies in mild cognitive impairment (MCI), a prodromal stage of Alzheimer's disease (AD), have demonstrated inconsistent yet promising results. Addressing the limitations of previous studies, this trial investigated the effects of a 12-month structured exercise program on the progression of MCI. The NeuroExercise study is a multicenter randomized controlled trial across three European countries (Ireland, Netherlands, Germany). Hundred and eighty-three individuals with amnestic MCI were included and were randomized to a 12-month exercise intervention (3 units of 45 min) of either aerobic exercise (AE; n = 60), stretching and toning exercise (ST; n = 65) or to a non-exercise control group (CG; n = 58). The primary outcome, cognitive performance, was determined by an extensive neuropsychological test battery. For the primary complete case (CC) analyses, between-group differences were analyzed with analysis of covariance under two conditions: (1) the exercise group (EG = combined AE and ST groups) compared to the CG and (2) AE compared to ST. Primary analysis of the full cohort (n = 166, 71.5 years; 51.8% females) revealed no between-group differences in composite cognitive score [mean difference (95% CI)], 0.12 [(-0.03, 0.27), p = 0.13] or in any cognitive domain or quality of life. VO2 peak was significantly higher in the EG compared to the CG after 12 months [-1.76 (-3.39, -0.10), p = 0.04]. Comparing the two intervention groups revealed a higher VO(2)peak level in the aerobic exercise compared to the stretching and toning group, but no differences for the other outcomes. A 12-month exercise intervention did not change cognitive performance in individuals with amnestic MCI in comparison to a non-exercise CG. An intervention effect on physical fitness was found, which may be an important moderator for long term disease progression and warrants long-term follow-up investigations.

引用

页数：12