Metabolic profile of the bioactive compounds of burdock (Arctium lappa) seeds, roots and leaves

被引:157
作者
Ferracane, Rosalia [1 ]
Graziani, Giulia [1 ]
Gallo, Monica [1 ]
Fogliano, Vincenzo [1 ]
Ritieni, Alberto [1 ]
机构
[1] Univ Naples Federico 2, Dept Food Sci, I-80055 Naples, Italy
关键词
Arcrium lappa; Lignan; Caffeoylquinic acid; Tandem mass spectrometry; Antioxidant activity; ANTIOXIDANT ACTIVITY; MASS-SPECTROMETRY; IDENTIFICATION; CHROMATOGRAPHY; ARCTIGENIN; LIGNANS; LINNE; CELLS; LIVER; ACID;
D O I
10.1016/j.jpba.2009.03.018
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
In this work the bioactive metabolic profile, the antioxidant activity and total phenolic content of burdock (Arctium lappa) seeds, leaves and roots were obtained. TEAC values and total phenolic content for hydroalcoholic extracts of burdock ranged from 67.39 to 1.63 mu mol Trolox equivalent/100 g dry weight (DW), and from 2.87 to 45 g of gallic acid equivalent/100g DW, respectively. Phytochemical compounds were analyzed by liquid Chromatography Coupled to electrospray tandem mass spectrometry (LC/MS/MS) in negative mode. The main compounds of burdock extracts were caffeoylquinic acid derivatives, lignans (mainly arctiin) and various flavonoids. The occurrence of some phenolic acids (caffeic acid, chlorogenic acid and cynarin) in burdock seeds; arctiin, luteolin and quercetin rhamnoside in burdock roots; phenolic acids, quercetin, quercitrin and luteolin in burdock leaves was reported for the first time. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:399 / 404
页数:6
相关论文
共 29 条
  • [1] Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation
    Awale, S
    Lu, J
    Kalauni, SK
    Kurashima, Y
    Tezuka, Y
    Kadota, S
    Esumi, H
    [J]. CANCER RESEARCH, 2006, 66 (03) : 1751 - 1757
  • [3] Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer
    Cai, YZ
    Luo, Q
    Sun, M
    Corke, H
    [J]. LIFE SCIENCES, 2004, 74 (17) : 2157 - 2184
  • [4] The influence of different treatments on the free radical scavenging activity of burdock and variations of its active components
    Chen, FA
    Wu, AB
    Chen, CY
    [J]. FOOD CHEMISTRY, 2004, 86 (04) : 479 - 484
  • [5] Information-dependent acquisition-mediated LC-MS/MS screening procedure with semiquantitative potential
    Decaestecker, TN
    Casteele, SRV
    Wallemacq, PE
    Van Peteghem, CH
    Defore, DL
    Van Bocxlaer, JF
    [J]. ANALYTICAL CHEMISTRY, 2004, 76 (21) : 6365 - 6373
  • [6] Antioxidant activity of burdock (Arctium lappa Linne):: Its scavenging effect on free-radical and active oxygen
    Duh, PD
    [J]. JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 1998, 75 (04) : 455 - 461
  • [7] Complementary and alternative medicine use by patients enrolled onto phase I clinical trials
    Dy, GK
    Bekele, L
    Hanson, LJ
    Furth, A
    Mandrekar, S
    Sloan, JA
    Adjei, AA
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (23) : 4810 - 4815
  • [8] Identification of lignans by liquid chromatography-electrospray ionization ion-trap mass spectrometry
    Eklund, Patrik C.
    Backman, M. Josefin
    Kronberg, Leif A.
    Smeds, Annika I.
    Sjoholm, Rainer E.
    [J]. JOURNAL OF MASS SPECTROMETRY, 2008, 43 (01): : 97 - 107
  • [9] Han C.M., 1995, AGR WORLD, V145, P55
  • [10] Li H. Y., 1995, Yaoxue Xuebao, V30, P41