Phosphoramidites: Marvellous ligands in catalytic asymmetric conjugate addition

被引：663

作者：

Feringa, BL ^{[1
]}

机构：

[1] Univ Groningen, Stratingh Inst, Dept Organ & Mol Inorgan Chem, NL-9747 AG Groningen, Netherlands

来源：

ACCOUNTS OF CHEMICAL RESEARCH | 2000年 / 33卷 / 06期

关键词：

D O I：

10.1021/ar990084k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The development of an efficient catalytic system for enantioselective carbon-carbon bond formation by 1,4-addition of organometallic reagents (organolithium, Grignard, and organozinc reagents) to enones is a major challenge in organic synthesis. This Account presents the breakthrough realized in this field using chiral phosphoramidite ligands for copper-catalyzed dialkylzinc additions. Applications in catalytic routes to cycloalkanones as well as tandem and annulation procedures with excellent enantioselectivities are discussed.

引用

页码：346 / 353

页数：8

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