Fluorinated succinic acid derivatives from new refrigerants via ozonolysis of haloalkenes

被引：22

作者：

Brown, SJ

Corr, S

Percy, JM ^{[1
]}

机构：

[1] Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England

[2] ICI Klea R&T, Runcorn WA7 4QD, Cheshire, England

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 27期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0040-4039(00)00804-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Fluoro- and di-fluoro allylic alcohols obtained from HFC-134a and HCFC-133a were transformed through [3,3]-sigmatropic rearrangements into 3-fluoro-4-halo-4-alkenoates with variable substitution at the 2- and 3-positions. Ozonolysis of the haloalkenes afforded the corresponding acyl halides which could be trapped with nucleophiles to afford fluorinated succinic acid derivatives in which the two carboxylic acid groups were differentiated. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：5269 / 5273

页数：5

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