Innate and acquired immunity in atherogenesis

被引：538

作者：

Binder, CJ ^{[1
]}

Chang, MK ^{[1
]}

Shaw, PX ^{[1
]}

Miller, YI ^{[1
]}

Hartvigsen, K ^{[1
]}

Dewan, A ^{[1
]}

Witztum, JL ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

来源：

NATURE MEDICINE | 2002年 / 8卷 / 11期

关键词：

D O I：

10.1038/nm1102-1218

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Traditional risk factors like hypercholesterolemia are important for atherogenesis, but it is now apparent that the immune system also plays an important role. Uncovering the mechanisms by which specific components of the immune system impact atherogenesis will not only provide new insights into the pathogenesis of lesion formation, but could also lead to novel therapeutic approaches that involve immune modulation.

引用

页码：1218 / 1226

页数：9

共 98 条

[1] Immunization of low-density lipoprotein receptor deficient (LDL-RD) mice with heat shock protein 65 (HSP-65) promotes early atherosclerosis [J].

Afek, A ;

George, J ;

Gilburd, B ;

Rauova, L ;

Goldberg, I ;

Kopolovic, J ;

Harats, D ;

Shoenfeld, Y .

JOURNAL OF AUTOIMMUNITY, 2000, 14 (02) :115-121

[2] Effect of immunization with homologous LDL and oxidized LDL on early atherosclerosis in hypercholesterolemic rabbits [J].

Ameli, S ;

HultgardhNilsson, A ;

Regnstrom, J ;

Calara, F ;

Yano, J ;

Cercek, B ;

Shah, PK ;

Nilsson, J .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1996, 16 (08) :1074-1079

[3] Dental infections and atherosclerosis [J].

Beck, JD ;

Pankow, J ;

Tyroler, HA ;

Offenbacher, S .

AMERICAN HEART JOURNAL, 1999, 138 (05) :S528-S533

[4] Evidence for a role of phospholipid oxidation products in atherogenesis [J].

Berliner, JA ;

Subbanagounder, G ;

Leitinger, N ;

Watson, AD ;

Vora, D .

TRENDS IN CARDIOVASCULAR MEDICINE, 2001, 11 (3-4) :142-147

[5] Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis [J].

Boring, L ;

Gosling, J ;

Cleary, M ;

Charo, IF .

NATURE, 1998, 394 (6696) :894-897

[6] The binding of oxidized low density lipoprotein to mouse CD36 is mediated in part by oxidized phospholipids that are associated with both the lipid and protein moieties of the lipoprotein [J].

Boullier, A ;

Gillotte, KL ;

Hörkkö, S ;

Green, SR ;

Friedmann, P ;

Dennis, EA ;

Witztum, JL ;

Steinberg, D ;

Quehenberger, O .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (13) :9163-9169

[7] ANTI-PHOSPHORYLCHOLINE ANTIBODIES OF THE T15 IDIOTYPE ARE OPTIMALLY PROTECTIVE AGAINST STREPTOCOCCUS-PNEUMONIAE [J].

BRILES, DE ;

FORMAN, C ;

HUDAK, S ;

CLAFLIN, JL .

JOURNAL OF EXPERIMENTAL MEDICINE, 1982, 156 (04) :1177-1185

[8] Influence of C3 deficiency on atherosclerosis [J].

Buono, C ;

Come, CE ;

Witztum, JL ;

Maguire, GF ;

Connelly, PW ;

Carroll, M ;

Lichtman, AH .

CIRCULATION, 2002, 105 (25) :3025-3031

[9] Protective immunity against atherosclerosis carried by B cells of hypercholesterolemic mice [J].

Caligiuri, G ;

Nicoletti, A ;

Poirier, B ;

Hansson, GK .

JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (06) :745-753

[10] C-reactive protein binds to both oxidized LDL and apoptotic cells through recognition of a common ligand: Phosphorylcholine of oxidized phospholipids [J].

Chang, MK ;

Binder, CJ ;

Torzewski, M ;

Witztum, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) :13043-13048

← 1 2 3 4 5 6 7 8 9 10 →