Biological evaluation and molecular docking studies of new curcuminoid derivatives: Synthesis and characterization

被引：35
作者：
Banuppriya, Govindharasu [1 ]
Sribalan, Rajendran [1 ]
Padmini, Vediappen [1 ]
Shanmugaiah, Vellasamy [2 ]
机构：
[1] Madurai Kamaraj Univ, Sch Chem, Dept Organ Chem, Madurai 625021, Tamil Nadu, India
[2] Madurai Kamaraj Univ, Sch Biol Sci, Dept Microbial Technol, Madurai 625021, Tamil Nadu, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 07期
关键词：
Dimethylaminocurcumin; Antioxidant; Anti-inflammatory; Antibacterial; Docking study; DIMETHYLAMINOMETHYL-SUBSTITUTED CURCUMIN; ANTIOXIDANT ACTIVITY; AQUEOUS SOLUBILITY; ANALOGS; DESIGN; INHIBITOR; ANTITUMOR;
D O I：
10.1016/j.bmcl.2016.02.066
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In the present study, three series of dimethylamino curcuminoids viz. 4-phenylaminomethyl curcumin (3a-d), arylidene curcumin (3e) and pyrazole curcumin (3f-i) derivatives have been synthesized and studied for their in vitro anti-inflammatory, antioxidant and antibacterial activities. Synthesized dimethylamino curcuminoid derivatives namely 3d, 3e, 3h and 3i have shown potent anti-inflammatory properties than parent curcumin. Molecular docking interactions of dimethylamino curcuminoids derivatives against cyclooxygenase enzymes (COX-1 and COX-2) were studied. (C) 2016 Elsevier Ltd. All rights reserved.
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收藏
页码：1655 / 1659
页数：5
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