The Potential of Circular RNAs as Cancer Biomarkers

被引：25

作者：

Brown, Jason R. ^{[1
]}

Chinnaiyan, Arul M. ^{[1
]}

机构：

[1] Univ Michigan Ann Arbor, Michigan Med, Rogel Canc Ctr, 5309 CCC 5940,1500 E Med Ctr Dr, Ann Arbor, MI 48109 USA

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2020年 / 29卷 / 12期

关键词：

CELL-FREE DNA; COPY NUMBER ABERRATIONS; COLORECTAL-CANCER; CLONAL HEMATOPOIESIS; SOMATIC MUTATIONS; PLASMA DNA; NONINVASIVE DETECTION; ONCOGENE MUTATIONS; RARE MUTATIONS; GENE-MUTATIONS;

D O I：

10.1158/1055-9965.EPI-20-0796

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Circular RNA (circRNA) is a covalently closed RNA structure that has several proposed functions related to cancer development. Recently, cancer-specific and tissue-specific circRNAs have been identified by high-throughput sequencing and are curated in publicly available databases. CircRNAs have features that are ideal properties of biomarkers, including conservation, abundance, and stability in plasma, saliva, and urine. Many circRNAs with predictive and prognostic significance in cancer have been described, and functional mechanisms for some circRNAs have been suggested. CircRNA also has great potential as a noninvasive biomarker for early cancer detection, although further investigation is necessary before clinical application is feasible.See all articles in this CEBP Focus section, "NCI Early Detection Research Network: Making Cancer Detection Possible."

引用

页码：2541 / 2555

页数：15

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