Tumor-Infiltrating Natural Killer Cells

被引：285
作者：
Cozar, Beatriz [1 ]
Greppi, Marco [1 ,2 ]
Carpentier, Sabrina [1 ]
Narni-Mancinelli, Emilie [3 ]
Chiossone, Laura [1 ]
Vivier, Eric [1 ,3 ,4 ]
机构：
[1] Innate Pharma, Innate Pharma Res Labs, Marseille, France
[2] Univ Genoa, Ctr Excellence Biomed Res, Genoa, Italy
[3] Aix Marseille Univ, INSERM, CNRS, CIML, Marseille, France
[4] Hop la Timone, AP HM, Serv Immunol, Marseille Immunopole, Marseille, France
来源：
CANCER DISCOVERY | 2021年 / 11卷 / 01期
基金：
欧盟地平线“2020”; 欧洲研究理事会;
关键词：
NK CELLS; LEUKEMIA-CELLS; POOR-PROGNOSIS; EXPRESSION; RECEPTOR; IDENTIFICATION; ACTIVATION; CYTOTOXICITY; EVASION; SUBSETS;
D O I：
10.1158/2159-8290.CD-20-0655
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Because of their potent antitumor activity and their proinflammatory role, natural killer (NK) cells are at the forefront of efforts to develop immuno-oncologic treatments. NK cells participate in immune responses to tumors by killing target cells and producing cytokines. However, in the immunosuppressive tumor microenvironment, NK cells become dysfunctional through exposure to inhibitory molecules produced by cancer cells, leading to tumor escape. We provide an overview of what is known about NK tumor infiltration and surveillance and about the mechanisms by which NK cells become dysfunctional.
引用
收藏
页码：34 / 44
页数：11
相关论文
共 99 条
  • [1] Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells
    Andre, Pascale
    Denis, Caroline
    Soulas, Caroline
    Bourbon-Caillet, Clarisse
    Lopez, Julie
    Arnoux, Thomas
    Blery, Mathieu
    Bonnafous, Cecile
    Gauthier, Laurent
    Morel, Ariane
    Rossi, Benjamin
    Remark, Romain
    Breso, Violette
    Bonnet, Elodie
    Habif, Guillaume
    Guia, Sophie
    Lalanne, Ana Ines
    Hoffmann, Caroline
    Lantz, Olivier
    Fayette, Jerome
    Boyer-Chammard, Agnes
    Zerbib, Robert
    Dodion, Pierre
    Ghadially, Hormas
    Jure-Kunkel, Maria
    Morel, Yannis
    Herbst, Ronald
    Narni-Mancinelli, Emilie
    Cohen, Roger B.
    Vivier, Eric
    [J]. CELL, 2018, 175 (07) : 1731 - +
  • [2] A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments
    Barry, Kevin C.
    Hsu, Joy
    Broz, Miranda L.
    Cueto, Francisco J.
    Binnewies, Mikhail
    Combes, Alexis J.
    Nelson, Amanda E.
    Loo, Kimberly
    Kumar, Raj
    Rosenblum, Michael D.
    Alvarado, Michael D.
    Wolf, Denise M.
    Bogunovic, Dusan
    Bhardwaj, Nina
    Daud, Adil, I
    Ha, Patrick K.
    Ryan, William R.
    Pollack, Joshua L.
    Samad, Bushra
    Asthana, Saurabh
    Chan, Vincent
    Krummel, Matthew F.
    [J]. NATURE MEDICINE, 2018, 24 (08) : 1178 - 1191
  • [3] Evidence for NK cell subsets based on chemokine receptor expression
    Berahovich, Robert D.
    Lai, Nu L.
    Wei, Zheng
    Lanier, Lewis L.
    Schall, Thomas J.
    [J]. JOURNAL OF IMMUNOLOGY, 2006, 177 (11) : 7833 - 7840
  • [4] Activating killer cell immunoglobulin-like receptors: Detection, function and therapeutic use
    Blunt, Matthew D.
    Khakoo, Salim I.
    [J]. INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 2020, 47 (01) : 1 - 12
  • [5] Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire
    Campbell, JJ
    Qin, SX
    Unutmaz, D
    Soler, D
    Murphy, KE
    Hodge, MR
    Wu, LJ
    Butcher, EC
    [J]. JOURNAL OF IMMUNOLOGY, 2001, 166 (11) : 6477 - 6482
  • [6] Primary Human Tumor Cells Expressing CD155 Impair Tumor Targeting by Down-Regulating DNAM-1 on NK Cells
    Carlsten, Mattias
    Norell, Hakan
    Bryceson, Yenan T.
    Poschke, Isabel
    Schedvins, Kjell
    Liunggren, Hans-Gustaf
    Kiessling, Rolf
    Malmberg, Karl-Johan
    [J]. JOURNAL OF IMMUNOLOGY, 2009, 183 (08) : 4921 - 4930
  • [7] A comprehensive approach to gene expression profiling in immune cells
    Carpentier, Sabrina
    Romagne, Francois
    Vivier, Eric
    [J]. TUMOR IMMUNOLOGY AND IMMUNOTHERAPY - INTEGRATED METHODS, PT B, 2020, 636 : 1 - 47
  • [8] Natural killer cells and other innate lymphoid cells in cancer
    Chiossone, Laura
    Dumas, Pierre-Yves
    Vienne, Margaux
    Vivier, Eric
    [J]. NATURE REVIEWS IMMUNOLOGY, 2018, 18 (11) : 671 - 688
  • [9] NKp46 expression on NK cells as a prognostic and predictive biomarker for response to allo-SCT in patients with AML
    Chretien, Anne-Sophie
    Devillier, Raynier
    Fauriat, Cyril
    Orlanducci, Florence
    Harbi, Samia
    Le Roy, Aude
    Rey, Jerome
    Borg, Gaelle Bouvier
    Gautherot, Emmanuel
    Hamel, Jean-Francois
    Ifrah, Norbert
    Lacombe, Catherine
    Cornillet-Lefebvre, Pascale
    Delaunay, Jacques
    Toubert, Antoine
    Arnoulet, Christine
    Vey, Norbert
    Blaise, Didier
    Olive, Daniel
    [J]. ONCOIMMUNOLOGY, 2017, 6 (12):
  • [10] Expression profiling of single cells and patient cohorts identifies multiple immunosuppressive pathways and an altered NK cell phenotype in glioblastoma
    Close, H. J.
    Stead, L. F.
    Nsengimana, J.
    Reilly, K. A.
    Droop, A.
    Wurdak, H.
    Mathew, R. K.
    Corns, R.
    Newton-Bishop, J.
    Melcher, A. A.
    Short, S. C.
    Cook, G. P.
    Wilson, E. B.
    [J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2020, 200 (01) : 33 - 44
12345678910