Tumor-Infiltrating Natural Killer Cells

被引：321

作者：

Cozar, Beatriz ^{[1
]}

Greppi, Marco ^{[1
,2
]}

Carpentier, Sabrina ^{[1
]}

Narni-Mancinelli, Emilie ^{[3
]}

Chiossone, Laura ^{[1
]}

Vivier, Eric ^{[1
,3
,4
]}

机构：

[1] Innate Pharma, Innate Pharma Res Labs, Marseille, France

[2] Univ Genoa, Ctr Excellence Biomed Res, Genoa, Italy

[3] Aix Marseille Univ, INSERM, CNRS, CIML, Marseille, France

[4] Hop la Timone, AP HM, Serv Immunol, Marseille Immunopole, Marseille, France

来源：

CANCER DISCOVERY | 2021年 / 11卷 / 01期

基金：

欧盟地平线“2020”; 欧洲研究理事会;

关键词：

NK CELLS; LEUKEMIA-CELLS; POOR-PROGNOSIS; EXPRESSION; RECEPTOR; IDENTIFICATION; ACTIVATION; CYTOTOXICITY; EVASION; SUBSETS;

D O I：

10.1158/2159-8290.CD-20-0655

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Because of their potent antitumor activity and their proinflammatory role, natural killer (NK) cells are at the forefront of efforts to develop immuno-oncologic treatments. NK cells participate in immune responses to tumors by killing target cells and producing cytokines. However, in the immunosuppressive tumor microenvironment, NK cells become dysfunctional through exposure to inhibitory molecules produced by cancer cells, leading to tumor escape. We provide an overview of what is known about NK tumor infiltration and surveillance and about the mechanisms by which NK cells become dysfunctional.

引用

页码：34 / 44

页数：11

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