Blastic Plasmacytoid Dendritic Cell Neoplasm-Current Insights

被引：32
作者：
Venugopal, Sangeetha [1 ]
Zhou, Selena [2 ]
El Jamal, Siraj M. [3 ]
Lane, Andrew A. [4 ]
Mascarenhas, John [1 ]
机构：
[1] Tisch Canc Inst, Div Hematol Oncol, New York, NY USA
[2] Icahn Sch Med Mt Sinai, New York, NY 10029 USA
[3] Icahn Sch Med Mt Sinai, Dept Pathol, New York, NY 10029 USA
[4] Harvard Med Sch, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
来源：
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA | 2019年 / 19卷 / 09期
关键词：
Acute leukemia; CD123; Myeloid neoplasms; SL-401; Tagraxofusp; WORLD-HEALTH-ORGANIZATION; INTERLEUKIN-3; RECEPTOR; RADIATION-THERAPY; MYELOID NEOPLASMS; ACUTE-LEUKEMIA; EXPRESSION; TUMOR; CD4(+); LYMPHOMA; MARKER;
D O I：
10.1016/j.clml.2019.06.002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare clonal hematologic malignancy of plasmacytoid dendritic cell precursors. The presentation and clinical course of BPDCN is widely heterogeneous and was most recently categorized as a distinct clinical entity by the World Health Organization in 2016. The expanded understanding of the pathobiology of BPDCN has improved diagnostic accuracy and informed novel targeted therapeutic options. The United States Food and Drug Administration-approval of tagraxofusp (SL-401) in December 2018 has focused attention on this leukemia frequently associated with skin involvement. Herein, we aim to: (1) review etiology; (2) summarize diagnostic criteria; and (3) discuss historic treatments and novel therapies for BPDCN.
引用
收藏
页码：545 / 554
页数：10
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