Fatal cerebral haemorrhage after liver transplantation in a patient with transthyretin variant (gly53glu) amyloidosis

被引：10
作者：
De Carolis, P.
Galeotti, M.
Ficarra, G.
Masetti, M.
Grimaldi, D.
Cortelli, P.
机构：
[1] Osped Lugo, Unita Operat Neurol, I-48022 Lugo, RA, Italy
[2] Policlin Modena, Dipartimento Sevizi Diagnost Lab & Med Legale Ana, Modena, Italy
[3] Univ Modena, Policlin Modena, Dipartimento Chirurg Gen & Specialita Chirurg, I-41100 Modena, Italy
[4] Univ Bologna, Dipartimento Sci Neurol, I-40126 Bologna, Italy
来源：
NEUROLOGICAL SCIENCES | 2006年 / 27卷 / 05期
关键词：
cerebral haemorrhage; liver transplantation; transthyretin amyloidosis;
D O I：
10.1007/s10072-006-0709-5
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Transthyretin (TTR) amyloidosis is a form of systemic amyloidosis caused by an amyloidogenetic TTR variant. The most common mutant forms of TTR are mainly produced by the liver and therefore orthotopic liver transplantation (OLT) is currently accepted as the only known curative treatment. We describe the clinical and pathological features of a patient with TTR variant (gly53glu) with TTR amyloid infiltration of the leptomeningeal vessels in whom fatal cerebral haemorrhage occurred two months after OLT, soon after severe viral pneumonia.
引用
收藏
页码：352 / 354
页数：3
相关论文
共 13 条
  • [1] A different amyloid formation mechanism: De novo oculoleptomeningeal amyloid deposits after liver transplantation
    Ando, Y
    Terazaki, H
    Nakamura, M
    Ando, E
    Haraoka, K
    Yamashita, T
    Ueda, M
    Okabe, H
    Sasaki, Y
    Tanihara, H
    Uchino, M
    Inomata, Y
    [J]. TRANSPLANTATION, 2004, 77 (03) : 345 - 349
  • [2] Oculoleptomeningeal amyloidosis in a large kindred with a new transthyretin variant Tyr69His
    Blevins, G
    Macaulay, R
    Harder, S
    Fladeland, D
    Yamashita, T
    Yazaki, M
    Asl, KH
    Benson, MD
    Donat, J
    [J]. NEUROLOGY, 2003, 60 (10) : 1625 - 1630
  • [3] Transthyretin Leu12Pro is associated with systemic, neuropathic and leptomeningeal amyloidosis
    Brett, M
    Persey, MR
    Reilly, MM
    Revesz, T
    Booth, DR
    Booth, SE
    Hawkins, PN
    Pepys, MB
    Morgan-Hughes, JA
    [J]. BRAIN, 1999, 122 : 183 - 190
  • [4] Recurrent subarachnoid hemorrhage associated with a new transthyretin variant (Gly53Glu)
    Ellie, E
    Camou, F
    Vital, A
    Rummens, C
    Grateau, G
    Delpech, M
    Valleix, S
    [J]. NEUROLOGY, 2001, 57 (01) : 135 - 137
  • [5] Familial meningocerebrovascular amyloidosis, Hungarian type, with mutant transthyretin (TTR Asp18Gly)
    Garzuly, F
    Wisniewski, T
    Brittig, F
    Budka, H
    [J]. NEUROLOGY, 1996, 47 (06) : 1562 - 1567
  • [6] Ten years of international experience with liver transplantation for familial amyloidotic polyneuropathy: Results from the familial amyloidotic polyneuropathy world transplant registry
    Herlenius, G
    Wilczek, HE
    Larsson, M
    Ericzon, BG
    [J]. TRANSPLANTATION, 2004, 77 (01) : 64 - 71
  • [7] Massive leptomeningeal amyloidosis associated with a Val30Met transthyretin gene
    Herrick, MK
    DeBruyne, K
    Horoupian, DS
    Skare, J
    Vanefsky, MA
    Ong, T
    [J]. NEUROLOGY, 1996, 47 (04) : 988 - 992
  • [8] Transthyretin amyloidosis and superficial siderosis of the CNS
    Mascalchi, M
    Salvi, FP
    Pirini, MG
    D'Errico, A
    Ferlini, A
    Lolli, F
    Plasmati, R
    Tessa, C
    Villari, N
    Tassinari, CA
    [J]. NEUROLOGY, 1999, 53 (07) : 1498 - 1503
  • [9] Transthyretin amyloidosis: A new mutation associated with dementia
    Petersen, RB
    Goren, H
    Cohen, M
    Richardson, SL
    Tresser, N
    Lynn, A
    Gali, M
    Estes, M
    Gambetti, P
    [J]. ANNALS OF NEUROLOGY, 1997, 41 (03) : 307 - 313
  • [10] Familial amyloidotic polyneuropathy (ATTR Val30Met) with widespread cerebral amyloid angiopathy and lethal cerebral hemorrhage
    Sakashita, N
    Ando, Y
    Jinnouchi, K
    Yoshimatsu, M
    Terazaki, H
    Obayashi, K
    Takeya, M
    [J]. PATHOLOGY INTERNATIONAL, 2001, 51 (06) : 476 - 480
12