Fatal cerebral haemorrhage after liver transplantation in a patient with transthyretin variant (gly53glu) amyloidosis

被引：10

作者：

De Carolis, P.

Galeotti, M.

Ficarra, G.

Masetti, M.

Grimaldi, D.

Cortelli, P.

机构：

[1] Osped Lugo, Unita Operat Neurol, I-48022 Lugo, RA, Italy

[2] Policlin Modena, Dipartimento Sevizi Diagnost Lab & Med Legale Ana, Modena, Italy

[3] Univ Modena, Policlin Modena, Dipartimento Chirurg Gen & Specialita Chirurg, I-41100 Modena, Italy

[4] Univ Bologna, Dipartimento Sci Neurol, I-40126 Bologna, Italy

来源：

NEUROLOGICAL SCIENCES | 2006年 / 27卷 / 05期

关键词：

cerebral haemorrhage; liver transplantation; transthyretin amyloidosis;

D O I：

10.1007/s10072-006-0709-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Transthyretin (TTR) amyloidosis is a form of systemic amyloidosis caused by an amyloidogenetic TTR variant. The most common mutant forms of TTR are mainly produced by the liver and therefore orthotopic liver transplantation (OLT) is currently accepted as the only known curative treatment. We describe the clinical and pathological features of a patient with TTR variant (gly53glu) with TTR amyloid infiltration of the leptomeningeal vessels in whom fatal cerebral haemorrhage occurred two months after OLT, soon after severe viral pneumonia.

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收藏

页码：352 / 354

页数：3

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