Regulation of redox balance in cancer and T cells

被引：130

作者：

Kong, Hyewon ^{[1
]}

Chandel, Navdeep S. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Med, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2018年 / 293卷 / 20期

关键词：

PYRUVATE-KINASE M2; OXIDATIVE STRESS; HYDROGEN-PEROXIDE; REVERSIBLE INACTIVATION; SUPEROXIDE ANION; ACTIVATION; ROS; ANTIOXIDANT; NRF2; MITOCHONDRIA;

D O I：

10.1074/jbc.TM117.000257

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reactive oxygen species (ROS) mediate redox signaling necessary for numerous cellular functions. Yet, high levels of ROS in cells and tissues can cause damage and cell death. Therefore, regulation of redox homeostasis is essential for ROS-dependent signaling that does not incur cellular damage. Cells achieve this optimal balance by coordinating ROS production and elimination. In this Minireview, we discuss the mechanisms by which proliferating cancer and T cells maintain a carefully controlled redox balance. Greater insight into such redox biology may enable precisely targeted manipulation of ROS for effective medical therapies against cancer or immunological disorders.

引用

页码：7499 / 7507

页数：9

共 99 条

[1] Perinuclear Mitochondrial Clustering Creates an Oxidant-Rich Nuclear Domain Required for Hypoxia-Induced Transcription [J].

Al-Mehdi, Abu-Bakr ;

Pastukh, Viktor M. ;

Swiger, Brad M. ;

Reed, Darla J. ;

Patel, Mita R. ;

Bardwell, Gina C. ;

Pastukh, Viktoriya V. ;

Alexeyev, Mikhail F. ;

Gillespie, Mark N. .

SCIENCE SIGNALING, 2012, 5 (231)

[2] ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS [J].

Alexander, Angela ;

Cai, Sheng-Li ;

Kim, Jinhee ;

Nanez, Adrian ;

Sahin, Mustafa ;

MacLean, Kirsteen H. ;

Inoki, Ken ;

Guan, Kun-Liang ;

Shen, Jianjun ;

Person, Maria D. ;

Kusewitt, Donna ;

Mills, Gordon B. ;

Kastan, Michael B. ;

Walker, Cheryl Lyn .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (09) :4153-4158

[3] Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses [J].

Anastasiou, Dimitrios ;

Poulogiannis, George ;

Asara, John M. ;

Boxer, Matthew B. ;

Jiang, Jian-kang ;

Shen, Min ;

Bellinger, Gary ;

Sasaki, Atsuo T. ;

Locasale, Jason W. ;

Auld, Douglas S. ;

Thomas, Craig J. ;

Vander Heiden, Matthew G. ;

Cantley, Lewis C. .

SCIENCE, 2011, 334 (6060) :1278-1283

[4] Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation [J].

Angelini, G ;

Gardella, S ;

Ardy, M ;

Ciriolo, MR ;

Filomeni, G ;

Di Trapani, G ;

Clarke, F ;

Sitia, R ;

Rubartelli, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (03) :1491-1496

[5] Regulation of reactive oxygen species generation in cell signaling [J].

Bae, Yun Soo ;

Oh, Hyunjin ;

Rhee, Sue Goo ;

Do Yoo, Young .

MOLECULES AND CELLS, 2011, 32 (06) :491-509

[6] The mitochondrial fission factor dynamin-related protein 1 modulates T-cell receptor signalling at the immune synapse [J].

Baixauli, Francesc ;

Martin-Cofreces, Noa B. ;

Morlino, Giulia ;

Carrasco, Yolanda R. ;

Calabia-Linares, Carmen ;

Veiga, Esteban ;

Serrador, Juan M. ;

Sanchez-Madrid, Francisco .

EMBO JOURNAL, 2011, 30 (07) :1238-1250

[7] Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer [J].

Bar-Peled, Liron ;

Kemper, Esther K. ;

Suciu, Radu M. ;

Vinogradova, Ekaterina V. ;

Backus, Keriann M. ;

Horning, Benjamin D. ;

Paul, Thomas A. ;

Ichu, Taka-Aki ;

Svensson, Robert U. ;

Olucha, Jose ;

Chang, Max W. ;

Kok, Bernard P. ;

Zhu, Zhou ;

Ihle, Nathan T. ;

Dix, Melissa M. ;

Jiang, Ping ;

Hayward, Matthew M. ;

Saez, Enrique ;

Shaw, Reuben J. ;

Cravatt, Benjamin F. .

CELL, 2017, 171 (03) :696-+

[8] The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology [J].

Bedard, Karen ;

Krause, Karl-Heinz .

PHYSIOLOGICAL REVIEWS, 2007, 87 (01) :245-313

[9] TIGAR, a p53-inducible regulator of glycolysis and apoptosis [J].

Bensaad, Karim ;

Tsuruta, Atsushi ;

Selak, Mary A. ;

Calvo Vidal, M. Nieves ;

Nakano, Katsunori ;

Bartrons, Ramon ;

Gottlieb, Eyal ;

Vousden, Karen H. .

CELL, 2006, 126 (01) :107-120

[10] Metabolic pathways promoting cancer cell survival and growth [J].

Boroughs, Lindsey K. ;

DeBerardinis, Ralph J. .

NATURE CELL BIOLOGY, 2015, 17 (04) :351-359

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