SYNTHESIS, ANTIMICROBIAL, ANALGESIC AND ANTIINFLAMMATORY ACTIVITIES OF SOME NOVEL PYRROLE DERIVATIVES

With an objective of synthesizing novel, potent antimicrobial, analgesic and antiinflammatory agents, here we have reported the synthesis of a novel series of pyrrole derivatives. The titled compounds (Va-o) were synthesized by the reaction of N-1-(3-chloropropionyl)-4-(1H-pyrrole-1-yl) benzohydrazide (IV) with different aromatic primary amines and triethylamine in presence of acetonitrile. Structures of the synthesized compounds were confirmed on the basis of physico-chemical and spectral data (IR, H-1 NMR,C-13 NMR and Mass). All the synthesized compounds were screened for their antimicrobial, analgesic and antiinflammatory activities using broth microdilution, Microplate Alamar Blue Assay (MABA), glacial acetic acid induced writhing in mice and carrageenan induced rat paw edema methods respectively. For antimicrobial, analgesic and antiinflammatory activities screening ciprofloxacin, norfloxacin, isoniazid, aspirin and diclofenac were used as standard drugs respectively. Among the synthesized compounds Vb, Vc, Vd, Vg, Vh, Vj and Vo have shown good antibacterial activity, compounds Vc, Vf, Vg, VI and Vn have shown good antitubercular activity, compounds Va, Vd, Vg, Vh, Vk, IVm, IVn and Vo showed good analgesic activity and compounds Va, Vd, Ve, Vg, Vf, Vi, Vk, VI, Vm, Vn and Vo showed good antiinflammatory activity