Natural History of Alcohol-Associated Liver Disease: Understanding the Changing Landscape of Pathophysiology and Patient Care

被引：12

作者：

Bajaj, Jasmohan S. ^{[1
,2
]}

Nagy, Laura E. ^{[3
,4
,5
]}

机构：

[1] Virginia Commonwealth Univ, Div Gastroenterol Hepatol & Nutr, 1201 Broad Rock Blvd, Richmond, VA 23249 USA

[2] Cent Virginia Vet Healthcare Syst, 1201 Broad Rock Blvd, Richmond, VA 23249 USA

[3] Cleveland Clin, Ctr Liver Dis Res, Dept Inflammat & Immun, Cleveland, OH 44106 USA

[4] Cleveland Clin, Dept Gastroenterol & Hepatol, Cleveland, OH 44106 USA

[5] Case Western Reserve Univ, Dept Mol Med, Cleveland, OH 44106 USA

来源：

GASTROENTEROLOGY | 2022年 / 163卷 / 04期

基金：

美国国家卫生研究院;

关键词：

USE DISORDER; CIRCULATING LEVELS; ADIPOSE-TISSUE; CELL-DEATH; LONG-TERM; HEPATITIS; DIAGNOSIS; CIRRHOSIS; OBESITY; RISK;

D O I：

10.1053/j.gastro.2022.05.031

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Alcohol use and consequent liver disease are major burdens that have worsened during the COVID-19 pandemic. There are several facets to the pathophysiology and clinical consequences of alcohol-use disorder (AUD) and progression to alcohol-associated liver disease (ALD) that require a concerted effort by clinicians and translational and basic science investigators. Several recent advances from bedside to bench and bench to bedside have been made in ALD. We focused this review on a case-based approach that provides a human context to these important advances across the spectrum of ALD.

引用

页码：840 / 851

页数：12

共 106 条

[1] Sex Differences in Alcohol Use Disorder [J].

Agabio, Roberta ;

Pisanu, Claudia ;

Gessa, Gian Luigi ;

Franconi, Flavia .

CURRENT MEDICINAL CHEMISTRY, 2017, 24 (24) :2661-2670

[2]

Amer Assoc Study Liver Dis, 2014, J HEPATOL, V61, P642, DOI 10.1016/j.jhep.2014.05.042

[3]

American Psychiatric Association, 2022, Diagnostic and statistical manual of mental disorders, V5th ed., text rev., DOI [10.1176/appi.books.9780890425596, DOI 10.1176/APPI.BOOKS.9780890425596]

[4] Efficacy of Gabapentin for the Treatment of Alcohol Use Disorder in Patients With Alcohol Withdrawal Symptoms A Randomized Clinical Trial [J].