Outcomes of surgical treatment in patients with anorectal fistula cancer

被引：6

作者：

Osone, Katsuya ^{[1
]}

Ogawa, Hiroomi ^{[1
]}

Katayama, Chika ^{[1
]}

Shibasaki, Yuta ^{[1
]}

Suga, Kunihiko ^{[1
]}

Komine, Chika ^{[1
]}

Ozawa, Naoya ^{[1
]}

Okada, Takuhisa ^{[1
]}

Shiraishi, Takuya ^{[1
]}

Katoh, Ryuji ^{[1
]}

Sakai, Makoto ^{[1
]}

Sano, Akihiko ^{[1
]}

Yokobori, Takehiko ^{[2
]}

Matsumura, Nozomi ^{[3
]}

Sohda, Makoto ^{[1
]}

Shirabe, Ken ^{[1
]}

Saeki, Hiroshi ^{[1
]}

机构：

[1] Gunma Univ, Grad Sch Med, Dept Gen Surg Sci, 3-39-22 Showa Machi, Maebashi, Gumma 3718511, Japan

[2] Gunma Univ Initiat Adv Res GIAR, Div Integrated Oncol Res, Maebashi, Gunma, Japan

[3] Gunma Univ, Grad Sch Med, Dept Human Pathol, Maebashi, Gunma, Japan

来源：

SURGICAL CASE REPORTS | 2021年 / 7卷 / 01期

关键词：

Anorectal fistula; Mucinous adenocarcinoma; Hyperthermo-chemoradiotherapy; FDG-PET; CT; Crohn's disease;

D O I：

10.1186/s40792-021-01118-6

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

BackgroundNo standard treatment for anorectal fistula cancer, such as multidisciplinary therapy, has been established due to the rarity of the disease. Herein, we investigated patients with cancer associated with anorectal fistula who underwent surgery to clarify the clinicopathological characteristics and to propose future perspectives for treatment strategies.Case presentationSeven patients with cancer associated with anorectal fistula who underwent rectal amputation in our institute were analyzed with regard to clinical characteristics, pathological findings, surgical results, and prognosis. Four cases had Crohn's disease as an underlying cause. All seven cases were diagnosed as advanced stage. Preoperative [F-18]-fluoro-2-deoxy-d-glucose (FDG)-positron emission tomography/computed tomography (FDG-PET/CT) showed abnormal FDG accumulation in six cases including four mucinous adenocarcinomas. Three cases that received preoperative hyperthermo-chemoradiotherapy achieved pathological R0 resection. Postoperative recurrence was observed in four cases including three with Crohn's disease and one resulting in death.ConclusionsAnorectal fistula cancer is rare and difficult to be diagnosed at early stages. Mucinous adenocarcinoma associated with anorectal fistula tends to exhibit abnormal FDG accumulation by FDG-PET/CT unlike common colorectal mucinous adenocarcinoma. Preoperative hyperthermo-chemoradiotherapy may be effective in obtaining pathological complete resection.

引用

页数：7

共 23 条

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