Effect of hot water extract from Agaricus blazei Murill on antibody-producing cells in mice

被引：56

作者：

Nakajima, A

Ishida, T

Koga, M

Takeuchi, T

Mazda, O

Takeuchi, M ^{[1
]}

机构：

[1] Kyoto Sangyo Univ, Fac Engn, Dept Biotechnol, Kita Ku, Kyoto 6038555, Japan

[2] Kagoshima Univ, Fac Med, Dept Hyg, Kagoshima 890, Japan

[3] Kyoto Prefectural Univ Med, Dept Microbiol, Kyoto 602, Japan

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2002年 / 2卷 / 08期

关键词：

Agaricus blazei Murill; antibody production; mice;

D O I：

10.1016/S1567-5769(02)00056-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated the inummopotentiating activities of boiled water-soluble extracts from desiccated Agaricus blazei Murill (ABM). Effect of ABM extract on antibody production was investigated by method of hemolytic plaque-forming cells (PFC) against sheep red blood cells (SRBC) antigen. ABM extracts significantly (p<0.01) increased the number of PFC in spleen with intraperitoneal administration at doses of 25 mg/kg as compared with control group. The populations of Mac-1- or CD25-positive cells significantly (p<0.01, p<0.00 1) increased, but in CD19-positive cells, there were no differences in ABM-treated mice as compared with control mice. The expressions of IL-6 and IL-1β mRNA were augmented by ABM extract in both peritoneal macrophages and spleen cells. These results suggested that ABM extract might be an effective stimulator for T cell and macrophage to IL-1β and IL-6 release, resulting in augmentation of antibody production against SRBC antigen.

引用

页码：1205 / 1211

页数：7

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