Allogeneic Hematopoietic Cell Transplantation for Myeloma: When and in Whom Does It Work

被引：13

作者：

Bashir, Qaiser ^{[1
]}

Qazilbash, Muzaffar H. ^{[1
]}

机构：

[1] UT MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, Div Canc Med, Houston, TX 77030 USA

来源：

CURRENT HEMATOLOGIC MALIGNANCY REPORTS | 2017年 / 12卷 / 02期

关键词：

Multiple myeloma; Allo-HCT; Autologous HCT; Allogeneic hematopoietic cell transplantation; Stem cell transplantation; VERSUS-HOST-DISEASE; MINIMAL RESIDUAL DISEASE; BONE-MARROW-TRANSPLANTATION; DONOR-LYMPHOCYTE INFUSION; RELAPSED MULTIPLE-MYELOMA; KIR ANTIBODY IPH2101; AUTOLOGOUS TRANSPLANTATION; LENALIDOMIDE MAINTENANCE; MOLECULAR REMISSION; GENETIC ABNORMALITIES;

D O I：

10.1007/s11899-017-0374-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The growing list of available therapies for patients with multiple myeloma has resulted in tremendously high response rates and prolonged survival. However, the cure remains elusive. A continued effort at developing strategies to utilize all available treatment modalities in the most effective manner is needed. Allogeneic hematopoietic cell transplantation (allo-HCT) is a robust platform, associated with high response rates, and provides a unique foundation on which immune therapies and novel agents can be employed to improve clinical outcomes. Patients with high-risk myeloma and those relapsing after novel agent-based therapies or early after an autologous HCT should be considered for allo-HCT, ideally in a clinical trial setting. Results from several ongoing studies are expected to provide important information that will help determine the place of allo-HCT in the myeloma treatment algorithm.

引用

页码：126 / 135

页数：10

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