The GDNF family ligands and receptors - implications for neural development

被引：398
作者：
Baloh, RH
Enomoto, H
Johnson, EM
Milbrandt, J
机构：
[1] Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Internal Med, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA
[4] Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA
来源：
CURRENT OPINION IN NEUROBIOLOGY | 2000年 / 10卷 / 01期
关键词：
D O I：
10.1016/S0959-4388(99)00048-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The glial cell line derived neurotrophic factor (GDNF) family has recently been expanded to include four members, and the interactions between these neurotrophic factors and their unique receptor system is now beginning to be understood. Furthermore, analysis of mice lacking the genes for GDNF, neurturin, and their related receptors has confirmed the importance of these factors in neurodevelopment, The results of such analyses reveal numerous similarities and potential overlaps in the way the GDNF and the nerve growth factor (NGF) families regulate development of the peripheral nervous system.
引用
收藏
页码：103 / 110
页数：8
相关论文
共 59 条
  • [21] GDNF and ET-3 differentially modulate the numbers of avian enteric neural crest cells and enteric neurons in vitro
    Hearn, CJ
    Murphy, M
    Newgreen, D
    [J]. DEVELOPMENTAL BIOLOGY, 1998, 197 (01) : 93 - 105
  • [22] GDNF - A POTENT SURVIVAL FACTOR FOR MOTONEURONS PRESENT IN PERIPHERAL-NERVE AND MUSCLE
    HENDERSON, CE
    PHILLIPS, HS
    POLLOCK, RA
    DAVIES, AM
    LEMEULLE, C
    ARMANINI, M
    SIMPSON, LC
    MOFFET, B
    VANDLEN, RA
    KOLIATSOS, VE
    ROSENTHAL, A
    [J]. SCIENCE, 1994, 266 (5187) : 1062 - 1064
  • [23] Neurturin and GDNF promote proliferation and survival of enteric neuron and glial progenitors in vitro
    Heuckeroth, RO
    Lampe, PA
    Johnson, EM
    Milbrandt, J
    [J]. DEVELOPMENTAL BIOLOGY, 1998, 200 (01) : 116 - 129
  • [24] Gene targeting reveals a critical role for neurturin in the development and maintenance of enteric, sensory, and parasympathetic neurons
    Heuckeroth, RO
    Enomoto, H
    Grider, JR
    Golden, JP
    Hanke, JA
    Jackman, A
    Molliver, DC
    Bardgett, ME
    Snider, WD
    Johnson, EM
    Milbrandt, J
    [J]. NEURON, 1999, 22 (02) : 253 - 263
  • [25] Emerging themes in structural biology of neurotrophic factors
    Ibáñez, CF
    [J]. TRENDS IN NEUROSCIENCES, 1998, 21 (10) : 438 - 444
  • [26] GFRα-2 and GFRα-3 are two new receptors for ligands of the GDNF family
    Jing, SQ
    Yu, YB
    Fang, M
    Hu, Z
    Holst, PL
    Boone, T
    Delaney, J
    Schultz, H
    Zhou, RP
    Fox, GM
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (52) : 33111 - 33117
  • [27] GDNF-induced activation of the Ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF
    Jing, SQ
    Wen, DZ
    Yu, YB
    Holst, PL
    Luo, Y
    Fang, M
    Tamir, R
    Antonio, L
    Hu, Z
    Cupples, R
    Louis, JC
    Hu, S
    Altrock, BW
    Fox, GM
    [J]. CELL, 1996, 85 (07) : 1113 - 1124
  • [28] A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor
    Klein, RD
    Sherman, D
    Ho, WH
    Stone, D
    Bennett, GL
    Moffat, B
    Vandlen, R
    Simmons, L
    Gu, QM
    Hongo, JA
    Devaux, B
    Poulsen, K
    Armanini, M
    Nozaki, C
    Asai, N
    Goddard, A
    Phillips, H
    Henderson, CE
    Takahashi, M
    Rosenthal, A
    [J]. NATURE, 1997, 387 (6634) : 717 - 721
  • [29] Neurturin, a relative of glial-cell-line-derived neurotrophic factor
    Kotzbauer, PT
    Lampe, PA
    Heuckeroth, RO
    Golden, JP
    Creedon, DJ
    Johnson, EM
    Milbrandt, J
    [J]. NATURE, 1996, 384 (6608) : 467 - 470
  • [30] EXPERIMENTAL ANALYSIS OF MIGRATION AND DIFFERENTIATION OF NEUROBLASTS OF AUTONOMIC NERVOUS-SYSTEM AND OF NEURECTODERMAL MESENCHYMAL DERIVATIVES, USING A BIOLOGICAL CELL MARKING TECHNIQUE
    LEDOUARI.NM
    TEILLET, MAM
    [J]. DEVELOPMENTAL BIOLOGY, 1974, 41 (01) : 162 - 184
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