Immune modulation of some autoimmune diseases: the critical role of macrophages and neutrophils in the innate and adaptive immunity

被引：262

作者：

Navegantes, Kely Campos ^{[1
]}

Gomes, Rafaelli de Souza ^{[1
]}

Tartari Pereira, Priscilla Aparecida ^{[2
]}

Czaikoski, Paula Giselle ^{[3
]}

Mares Azevedo, Carolina Heitmann ^{[1
]}

Monteiro, Marta Chagas ^{[1
]}

机构：

[1] Fed Univ Para UFPA, Hlth Sci Inst, Pharmaceut Sci Postgrad Program, BR-66075900 Belem, Para, Brazil

[2] Univ Sao Paulo, Ribeirao Preto Pharmaceut Sci Sch, Dept Clin Bromatol & Toxicol Anal, Ribeirao Preto, SP, Brazil

[3] Guairaca Fac PR, Coll Pharm, Guarapuava, PR, Brazil

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2017年 / 15卷

关键词：

Macrophages; Neutrophils; Autoimmunity; Autoimmune disease; Inflammation; TUMOR-NECROSIS-FACTOR; COLONY-STIMULATING FACTOR; TYPE-1; DIABETES-MELLITUS; MONONUCLEAR PHAGOCYTE SYSTEM; FIBROBLAST-LIKE SYNOVIOCYTES; COLLAGEN-INDUCED ARTHRITIS; ANTIGEN-PRESENTING CELLS; RHEUMATOID-ARTHRITIS; DENDRITIC CELLS; TNF-ALPHA;

D O I：

10.1186/s12967-017-1141-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Macrophages and neutrophils are key components involved in the regulation of numerous chronic inflammatory diseases, infectious disorders, and especially certain autoimmune disease. However, little is known regarding the contribution of these cells to the pathogenesis of autoimmune disorders. Recent studies have aimed to clarify certain important factors affecting the immunogenicity of these cells, including the type and dose of antigen, the microenvironment of the cell-antigen encounter, and the number, subset, and phenotype of these cells, which can prevent or induce autoimmune responses. This review highlights the role of macrophage subsets and neutrophils in injured tissues, supporting their cooperation during the pathogenesis of certain autoimmune diseases.

引用

页数：21

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