Fragment-Based Lead Discovery

[1] Ligand efficiency indices as guideposts for drug discovery [J]. DRUG DISCOVERY TODAY, 2005, 10 (07) : 464 - 469

[2] Deconstructing fragment-based inhibitor discovery [J]. NATURE CHEMICAL BIOLOGY, 2006, 2 (12) : 720 - 723

[3] Babine R. E., 2004, LETT DRUG DES DISCOV, V1, P173

[4] Fragment screening by biochemical assay [J]. EXPERT OPINION ON DRUG DISCOVERY, 2006, 1 (03) : 225 - 236

[5] Structure-activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (33) : 12602 - 12606

[6] Structure-based design of protein tyrosine phosphatase-1B inhibitors [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (10) : 2503 - 2507

[7] Blaney J., 2006, FRAGMENT BASED APPRO, P215

[8] Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (20) : 5939 - 5946

[9] A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design [J]. NATURE BIOTECHNOLOGY, 2005, 23 (02) : 201 - 207

[10] Fragment-based lead discovery: leads by design [J]. DRUG DISCOVERY TODAY, 2005, 10 (14) : 987 - 992

[1] Ligand efficiency indices as guideposts for drug discovery [J]. DRUG DISCOVERY TODAY, 2005, 10 (07) : 464 - 469

[2] Deconstructing fragment-based inhibitor discovery [J]. NATURE CHEMICAL BIOLOGY, 2006, 2 (12) : 720 - 723

[3] Babine R. E., 2004, LETT DRUG DES DISCOV, V1, P173

[4] Fragment screening by biochemical assay [J]. EXPERT OPINION ON DRUG DISCOVERY, 2006, 1 (03) : 225 - 236

[5] Structure-activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (33) : 12602 - 12606

[6] Structure-based design of protein tyrosine phosphatase-1B inhibitors [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (10) : 2503 - 2507

[7] Blaney J., 2006, FRAGMENT BASED APPRO, P215

[8] Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (20) : 5939 - 5946

[9] A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design [J]. NATURE BIOTECHNOLOGY, 2005, 23 (02) : 201 - 207

[10] Fragment-based lead discovery: leads by design [J]. DRUG DISCOVERY TODAY, 2005, 10 (14) : 987 - 992