Self-Assembly and Drug Delivery Behaviors of Thermo-Sensitive poly(t-butyl acrylate)-b-poly (N-isopropylacrylamide) Micelles

被引：22

作者：

Li, Guiying ^{[1
]}

Guo, Lei ^{[1
]}

Ma, Songmei ^{[1
]}

机构：

[1] Ludong Univ, Coll Chem & Mat Sci, Yantai 264025, Peoples R China

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2009年 / 113卷 / 02期

关键词：

block copolymer; controlled release; core-shell micelles; PtBA-b-PNIPAM; self-assembly; DIBLOCK COPOLYMERS; POLYMERIC MICELLES; BLOCK-COPOLYMERS; DOXORUBICIN; RELEASE; CARRIER; GRAFT;

D O I：

10.1002/app.30033

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Self-assembly of thermo-sensitive poly (t-butyl acrylate)-b-poly(N-isopropylacrylamide) (PtBA-b-PNIPAM) micelles in aqueous medium and its applications in controlled release of hydrophobic drugs were described. PtBA-b-PNIPAM was synthesized by atom transfer radical polymerization and aggregated into thermo-sensitive core-shell micelles with regular spheres in water, which was confirmed by (1)H-NMR, fluorescence spectroscopy, transmission electron microscopic (TEM), and UV-vis spectroscopic techniques. The critical micelle concentration of micelles decreased with the increase of the hydrophobic components. The anti-inflammation drug naproxen (NAP) was loaded as the model drug into polymeric micelles, which showed a dramatic thermo-sensitive fast/slow switching behavior around the lower critical solution temperature (LCST). When the temperature was enhanced above LCST, release of NAP from core-shell micelles was accelerated ascribed to the temperature-induced deformation of micelles. (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 113: 1364-1368, 2009

引用

页码：1364 / 1368

页数：5

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