Investigation of Inclusion Complex of Patchouli Alcohol with β-Cyclodextrin

被引：10

作者：

Xu, Fangfang ^{[1
]}

Yang, Qiuxia ^{[1
,2
]}

Wu, Lilan ^{[1
]}

Qi, Rui ^{[1
]}

Wu, Yunshan ^{[1
]}

Li, Yucui ^{[3
]}

Tang, Lipeng ^{[1
]}

Guo, De-an ^{[1
,2
,4
]}

Liu, Bo ^{[1
]}

机构：

[1] Guangzhou Univ Chinese Med, Guangdong Prov Acad Chinese Med Sci, Affiliated Hosp 2, Guangzhou, Guangdong, Peoples R China

[2] Guangdong Pharmaceut Univ, Coll Tradit Chinese Med, Guangzhou, Guangdong, Peoples R China

[3] Guangzhou Univ Chinese Med, Coll Chinese Med, Guangzhou, Guangdong, Peoples R China

[4] Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai, Peoples R China

来源：

PLOS ONE | 2017年 / 12卷 / 01期

基金：

中国国家自然科学基金;

关键词：

POGOSTEMONIS HERBA; CABLIN;

D O I：

10.1371/journal.pone.0169578

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The objective of this study was to improve the stability and water-solubility of patchouli alcohol by complexing with beta-cyclodextrin (beta-CD). The interactions between patchouli alcohol and beta-CD were characterized by differential scanning calorimetry (DSC), Fourier transformation -infrared (FT-IR) spectroscopy, powder X-ray diffraction (PXRD), and Scanning electron microscope (SEM), respectively. According to molecular modeling method, the enthalpy formation of host-guest illustrated the predominant configuration and the lowest value Delta(b)G degrees was-10.8174+/-1.9235 kcal/mol, suggesting the complex could reduce the energy of the system. The characterization analysis confirmed the formation of PA-CD inclusion complex, and the results indicated the advantage of the inclusion complex in stability and dissolution rates. These results identified PA-CD inclusion complex an effective way for the storage of PA, and better inclusion method still needed to be studied.

引用

页数：10

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