Investigation of Inclusion Complex of Patchouli Alcohol with β-Cyclodextrin

被引：10
|
作者：
Xu, Fangfang [1 ]
Yang, Qiuxia [1 ,2 ]
Wu, Lilan [1 ]
Qi, Rui [1 ]
Wu, Yunshan [1 ]
Li, Yucui [3 ]
Tang, Lipeng [1 ]
Guo, De-an [1 ,2 ,4 ]
Liu, Bo [1 ]
机构：
[1] Guangzhou Univ Chinese Med, Guangdong Prov Acad Chinese Med Sci, Affiliated Hosp 2, Guangzhou, Guangdong, Peoples R China
[2] Guangdong Pharmaceut Univ, Coll Tradit Chinese Med, Guangzhou, Guangdong, Peoples R China
[3] Guangzhou Univ Chinese Med, Coll Chinese Med, Guangzhou, Guangdong, Peoples R China
[4] Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai, Peoples R China
来源：
PLOS ONE | 2017年 / 12卷 / 01期
基金：
中国国家自然科学基金;
关键词：
POGOSTEMONIS HERBA; CABLIN;
D O I：
10.1371/journal.pone.0169578
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The objective of this study was to improve the stability and water-solubility of patchouli alcohol by complexing with beta-cyclodextrin (beta-CD). The interactions between patchouli alcohol and beta-CD were characterized by differential scanning calorimetry (DSC), Fourier transformation -infrared (FT-IR) spectroscopy, powder X-ray diffraction (PXRD), and Scanning electron microscope (SEM), respectively. According to molecular modeling method, the enthalpy formation of host-guest illustrated the predominant configuration and the lowest value Delta(b)G degrees was-10.8174+/-1.9235 kcal/mol, suggesting the complex could reduce the energy of the system. The characterization analysis confirmed the formation of PA-CD inclusion complex, and the results indicated the advantage of the inclusion complex in stability and dissolution rates. These results identified PA-CD inclusion complex an effective way for the storage of PA, and better inclusion method still needed to be studied.
引用
收藏
页数：10
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