Predictive value of combined amniotic fluid proteomic biomarkers and interleukin-6 in preterm labor with intact membranes

被引：50

作者：

Cobo, Teresa ^{[1
]}

Palacio, Montse ^{[1
,4
]}

Navarro-Sastre, Aleix ^{[2
,4
]}

Ribes, Antonia ^{[2
,4
]}

Bosch, Jordi ^{[3
]}

Filella, Xavier ^{[2
]}

Gratacos, Eduard ^{[1
,4
]}

机构：

[1] Univ Barcelona, Inst Invest Biomed August Pisunyer IDIBAPS, Hosp Clin, Dept Maternal Fetal Med, Barcelona, Spain

[2] Univ Barcelona, Inst Invest Biomed August Pisunyer IDIBAPS, Hosp Clin, Dept Biochem & Mol Genet, Barcelona, Spain

[3] Univ Barcelona, Inst Invest Biomed August Pisunyer IDIBAPS, Hosp Clin, Dept Microbiol, Barcelona, Spain

[4] Univ Barcelona, Inst Invest Biomed August Pi Sunyer IDIBAPS, Hosp Clin, CIBER Enfermedades Raras CIBERER, Barcelona, Spain

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2009年 / 200卷 / 05期

关键词：

interleukin-6; intraamniotic infection; preterm labor with intact membranes; proteomic biomarkers; BLOOD-CELL COUNT; INTRAAMNIOTIC INFLAMMATION; MICROBIAL INVASION; GRAM STAIN; INFECTION; IDENTIFICATION; GLUCOSE;

D O I：

10.1016/j.ajog.2008.12.036

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: To assess proteomic biomarkers and interleukin-6 alone or in combination to predict intraamniotic infection, preterm birth, and neonatal morbidity in preterm labor with intact membranes. STUDY DESIGN: Amniotic fluid interleukin-6 and selected proteomic biomarkers were assayed from 86 patients with preterm labor and intact membranes (22-36 weeks). The predictive value of each marker alone or in combination was evaluated for intraamniotic infection, preterm birth, and neonatal composite morbidity. RESULTS: Both interleukin-6 (odds ratio, 19.5; P = .012) and proteomic biomarkers (odds ratio, 25.2; P = .001) were statistically independent predictors of intraamniotic infection with sensitivity, positive predictive value, and false-positive rates of 25%, 17.6%, and 20% when 1 marker was present and of 75%, 75%, and 4.3% when both were detected. Their combination did not improve prediction of preterm birth or neonatal morbidity. CONCLUSION: The combined use of proteomic biomarkers and interleukin-6 to predict intraamniotic infection shows better accuracy than when used alone.

引用

页码：499.e1 / 499.e6

页数：6

共 16 条

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