Soluble T cell immunoglobulin and mucin-domain containing protein 3 in children hospitalized with pneumonia in resource-limited settings

被引：3

作者：

Ahmed, Usman ^{[1
]}

Soo, Jeremy ^{[1
]}

Conroy, Andrea L. ^{[2
]}

Namasopo, Sophie ^{[3
]}

Opoka, Robert O. ^{[4
,5
]}

Bhargava, Ravi ^{[6
]}

Hawkes, Michael T. ^{[1
,7
,8
,9
,10
]}

机构：

[1] Univ Alberta, Dept Pediat, 3-588D Edmonton Clin Hlth Acad,11405 87 Ave NW, Edmonton, AB T6G 1C9, Canada

[2] Indiana Univ Sch Med, Ryan White Ctr Pediat Infect Dis & Global Hlth, Indianapolis, IN USA

[3] Kabale Dist Hosp, Dept Paediat, Kabale, Uganda

[4] Mulago Hosp, Dept Paediat & Child Hlth, Kampala, Uganda

[5] Makerere Univ, Kampala, Uganda

[6] Univ Alberta, Dept Radiol & Diagnost Imaging, Edmonton, AB, Canada

[7] Univ Alberta, Dept Med Microbiol & Immunol, Edmonton, AB, Canada

[8] Univ Alberta, Sch Publ Hlth, Edmonton, AB, Canada

[9] Stollery Sci Lab, Edmonton, AB, Canada

[10] Women & Childrens Hlth Res Inst, Edmonton, AB, Canada

来源：

CYTOKINE | 2022年 / 151卷

关键词：

sTIM-3; Pediatric pneumonia; Respiratory Index of Severity in Children; Biomarker; Africa; Prospective cohort study; RESPIRATORY RATE; DIAGNOSIS; DISEASE; HEART;

D O I：

10.1016/j.cyto.2022.155794

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Y In a prospective cohort study of 77 children with severe pneumonia from two hospitals in Uganda, we assessed soluble T cell immunoglobulin and mucin-domain containing protein 3 (sTIM-3) levels at hospital admission and their association with pneumonia severity and subsequent mortality. sTIM-3 levels were positively correlated with the Respiratory Index of Severity in Children (RISC) (rho = 0.35, p = 0.0017), sTIM-3 levels were higher in children who required transfer to a tertiary hospital (p = 0.014) and in fatal cases (p = 0.011). In summary, sTIM-3 is associated with disease severity and predictive of mortality in childhood pneumonia in resource-limited settings.

引用

页数：4

共 15 条

[1]

[Anonymous], 1991, TECHN BAS WHO REC MA

[2] Density of Upper Respiratory Colonization With Streptococcus pneumoniae and Its Role in the Diagnosis of Pneumococcal Pneumonia Among Children Aged <5 Years in the PERCH Study [J].

Baggett, Henry C. ;

Watson, Nora L. ;

Knoll, Maria Deloria ;

Brooks, W. Abdullah ;

Feikin, Daniel R. ;

Hammitt, Laura L. ;

Howie, Stephen R. C. ;

Kotloff, Karen L. ;

Levine, Orin S. ;

Madhi, Shabir A. ;

Murdoch, David R. ;

Scott, J. Anthony G. ;

Thea, Donald M. ;

Antonio, Martin ;

Awori, Juliet O. ;

Baillie, Vicky L. ;

DeLuca, Andrea N. ;

Driscoll, Amanda J. ;

Duncan, Julie ;

Ebruke, Bernard E. ;

Goswami, Doli ;

Higdon, Melissa M. ;

Karron, Ruth A. ;

Moore, David P. ;

Morpeth, Susan C. ;

Mulindwa, Justin M. ;

Park, Daniel E. ;

Paveenkittiporn, Wantana ;

Piralam, Barameht ;

Prosperi, Christine ;

Sow, Samba O. ;

Tapia, Milagritos D. ;

Zaman, Khalequ ;

Zeger, Scott L. ;

O'Brien, Katherine L. .

CLINICAL INFECTIOUS DISEASES, 2017, 64 :S317-S327

[3] Development of Heart and Respiratory Rate Percentile Curves for Hospitalized Children [J].

Bonafide, Christopher P. ;

Brady, Patrick W. ;

Keren, Ron ;

Conway, Patrick H. ;

Marsolo, Keith ;

Daymont, Carrie .

PEDIATRICS, 2013, 131 (04) :E1150-E1157

[4]

Cherian T, 2005, B WORLD HEALTH ORGAN, V83, P353

[5] Normal ranges of heart rate and respiratory rate in children from birth to 18 years of age: a systematic review of observational studies [J].

Fleming, Susannah ;

Thompson, Matthew ;

Stevens, Richard ;

Heneghan, Carl ;

Plueddemann, Annette ;

Maconochie, Ian ;

Tarassenko, Lionel ;

Mant, David .

LANCET, 2011, 377 (9770) :1011-1018

[6] Soluble form of T cell ig mucin 3 is an inhibitory molecule in T cell-mediated immune response [J].

Geng, H ;

Zhang, GM ;

Li, D ;

Zhang, H ;

Yuan, Y ;

Zhu, HG ;

Xiao, H ;

Han, LF ;

Feng, ZH .

JOURNAL OF IMMUNOLOGY, 2006, 176 (03) :1411-1420

[7] Global, regional, and national estimates of pneumonia morbidity and mortality in children younger than 5 years between 2000 and 2015: a systematic analysis [J].

McAllister, David A. ;

Liu, Li ;

Shi, Ting ;

Chu, Yue ;

Reed, Craig ;

Burrows, John ;

Adeloye, Davies ;

Rudan, Igor ;

Black, Robert E. ;

Campbell, Harry ;

Nair, Harish .

LANCET GLOBAL HEALTH, 2019, 7 (01) :E47-E57

[8] Sample Size Calculation Guide - Part 7: How to Calculate the Sample Size Based on a Correlation [J].

Negida, Ahmed .

ADVANCED JOURNAL OF EMERGENCY MEDICINE, 2020, 4 (02)

[9] Biomarkers in Pediatric Community-Acquired Pneumonia [J].

Principi, Nicola ;

Esposito, Susanna .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (02)

[10] Development of the Respiratory Index of Severity in Children (RISC) Score among Young Children with Respiratory Infections in South Africa [J].

Reed, Carrie ;

Madhi, Shabir A. ;

Klugman, Keith P. ;

Kuwanda, Locadiah ;

Ortiz, Justin R. ;

Finelli, Lyn ;

Fry, Alicia M. .

PLOS ONE, 2012, 7 (01)

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