Multi-Dimensional High-Performance Liquid Chromatographic Determination of Chiral Amino Acids and Related Compounds in Real World Samples

被引：43

作者：

Ishii, Chiharu ^{[1
]}

Furusho, Aogu ^{[1
]}

Hsieh, Chin-Ling ^{[1
]}

Hamase, Kenji ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Pharmaceut Sci, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan

来源：

CHROMATOGRAPHY | 2020年 / 41卷 / 01期

关键词：

Chiral separation; Multi-dimensional HPLC; Amino acids; Hydroxy acids; D-ALANINE; D-SERINE; FLUOROMETRIC-DETERMINATION; LACTATE LEVELS; LACTIC-ACID; HPLC SYSTEM; ENANTIOSELECTIVE DETERMINATION; 3-HYDROXYBUTYRATE ENANTIOMERS; STATIONARY-PHASE; REVERSED-PHASE;

D O I：

10.15583/jpchrom.2020.004

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Chiral amino acid analysis, especially the determination of trace levels of D-enantiomers, is currently gathering attention in a variety of research areas including the food/clinical sciences. These D-amino acids had long been believed to be absent in the higher animals. However, by the advances of analytical technologies, some of the D-enantiomers are found in mammals including humans and increasingly recognized as novel physiologically-active substances and/or biomarkers. For the determination of these D-amino acids and related compounds in real world samples, utilization of sensitive and selective methods is essential and multi-dimensional HPLC is one of the straightforward approaches. In the present review, two/three-dimensional HPLC methods and biological/medical applications focusing on our current studies are summarized.

引用

页码：1 / 17

页数：17

共 81 条

[1] D-lactic acidosis in humans: systematic literature review [J].

Bianchetti, Davide G. A. M. ;

Amelio, Giacomo S. ;

Lava, Sebastiano A. G. ;

Bianchetti, Mario G. ;

Simonetti, Giacomo D. ;

Agostoni, Carlo ;

Fossali, Emilio F. ;

Milani, Gregorio P. .

PEDIATRIC NEPHROLOGY, 2018, 33 (04) :673-681

[2] Chiral separation of disease biomarkers with 2-hydroxycarboxylic acid structure [J].

Calderon, Carlos ;

Santi, Cristina ;

Laemmerhofer, Michael .

JOURNAL OF SEPARATION SCIENCE, 2018, 41 (06) :1224-1231

[3] Construction of a light-emitting diode fluorescence detector for high-performance liquid chromatography and its application to fluorometric determination of l-3-hydroxybutyrate [J].

Chen, Chien-Ming ;

Lee, Jen-Ai ;

Huang, Tzu-Chuan .

BIOMEDICAL CHROMATOGRAPHY, 2012, 26 (02) :256-260

[4] Elevated urinary D-lactate levels in patients with diabetes and microalbuminuria [J].

Chou, Chu-Kuang ;

Lee, Ya-Ting ;

Chen, Shih-Ming ;

Hsieh, Chi-Wen ;

Huang, Tzu-Chuan ;

Li, Yi-Chieh ;

Lee, Jen-Ai .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2015, 116 :65-70

[5] FURTHER STUDY ON THE SPECIFICITY OF D-AMINO-ACID OXIDASE AND OF D-ASPARTATE OXIDASE AND TIME-COURSE FOR COMPLETE OXIDATION OF D-AMINO ACIDS [J].

DANIELLO, A ;

VETERE, A ;

PETRUCELLI, L .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 1993, 105 (3-4) :731-734

[6] Separation and determination of the enantiomers of lactic acid and 2-hydroxyglutaric acid by chiral derivatization combined with gas chromatography and mass spectrometry [J].

Ding, Xuemei ;

Lin, Shuhai ;

Weng, Hongbo ;

Liang, Jianying .

JOURNAL OF SEPARATION SCIENCE, 2018, 41 (12) :2576-2584

[7] Enantioselective visualization of D-alanine in rat anterior pituitary gland: localization to ACTH-secreting cells [J].

Etoh, Sachise ;

Hamase, Kenji ;

Morikawa, Akiko ;

Ohgusu, Tomohiro ;

Zaitsu, Kiyoshi .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2009, 393 (01) :217-223

[8] D-Amino acids in aged proteins: Analysis and biological relevance [J].

Fujii, Noriko ;

Kaji, Yuichi ;

Fujii, Norihiko .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2011, 879 (29) :3141-3147

[9] ENANTIOMERIC SEPARATION AND SENSITIVE DETERMINATION OF D,L-AMINO ACIDS DERIVATIZED WITH FLUOROGENIC BENZOFURAZAN REAGENTS ON PIRKLE TYPE STATIONARY PHASES [J].

FUKUSHIMA, T ;

KATO, M ;

SANTA, T ;

IMAI, K .

BIOMEDICAL CHROMATOGRAPHY, 1995, 9 (01) :10-17

[10] Three-Dimensional High-Performance Liquid Chromatographic Determination of Asn, Ser, Ala, and Pro Enantiomers in the Plasma of Patients with Chronic Kidney Disease [J].

Furusho, Aogu ;

Koga, Reiko ;

Akita, Takeyuki ;

Mita, Masashi ;

Kimura, Tomonori ;

Hamase, Kenji .

ANALYTICAL CHEMISTRY, 2019, 91 (18) :11569-11575

← 1 2 3 4 5 6 7 8 9 →