Defining the toxic mode of action of esther sulphonates using the joint toxicity of mixtures

被引:23
|
作者
Hodges, Geoff [1 ]
Roberts, David W.
Marshall, Stuart J.
Dearden, John C.
机构
[1] Unilever Res Labs Colworth, SEAC, Sharnbrook MK44 1LQ, Beds, England
[2] Liverpool John Moores Univ, Sch Pharm & Chem, Liverpool L3 3AF, Merseyside, England
关键词
ester sulphonates; anionic surfactant; phenol; Daphnia magna; mixture toxicity;
D O I
10.1016/j.chemosphere.2005.12.021
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Previously we have presented aquatic toxicity data for the class of anionic surfactant ester sulphonates (ES) to Daphnia magna. We now present toxicity data for binary mixtures of ES substances with reference substances of known mode of action. Using a toxic unit (TU) approach, data indicated that ES substances exhibit concentration addition with linear alkylbenzene sulphonate (LAS) and phenols and response addition with alcohols. This suggests that ES behave with a similar mode of action to phenol and LAS which are known polar narcotics and with a dissimilar mode of action to alcohols which are known baseline narcotics. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:17 / 25
页数:9
相关论文
共 50 条
  • [21] Analysis of the toxic mode of action of silver nanoparticles using stress-specific bioluminescent bacteria
    Hwang, Ee Taek
    Lee, Jin Hyung
    Chae, Yun Ju
    Kim, Yeon Seok
    Kim, Byoung Chan
    Sang, Byoung-In
    Gu, Man Bock
    SMALL, 2008, 4 (06) : 746 - 750
  • [22] Prediction of aquatic toxicity mode of action using linear discriminant and random forest models
    Martin, Todd M.
    Grulke, Christopher M.
    Young, Douglas M.
    Russom, Christine L.
    Wang, Nina
    Jackson, Crystal R.
    Barron, Mace G.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 246
  • [23] Prediction of Aquatic Toxicity Mode of Action Using Linear Discriminant and Random Forest Models
    Martin, Todd M.
    Grulke, Christopher M.
    Young, Douglas M.
    Russom, Christine L.
    Wang, Nina Y.
    Jackson, Crystal R.
    Barron, Mace G.
    JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2013, 53 (09) : 2229 - 2239
  • [24] Predicting the aquatic toxicity mode of action using logistic regression and linear discriminant analysis
    Ren, Y. Y.
    Zhou, L. C.
    Yang, L.
    Liu, P. Y.
    Zhao, B. W.
    Liu, H. X.
    SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 2016, 27 (09) : 721 - 746
  • [25] Mode of joint action response to binary mixtures of three refined petroleum products by Nile tilapia Oreochromis niloticus fingerlings
    Chukwuand, L. O.
    Okhumale, B. O.
    SCIENTIFIC RESEARCH AND ESSAYS, 2009, 4 (08): : 806 - 811
  • [26] Species differences in response to toxic substances: Shared pathways of toxicity - Value and limitations of omics technologies to elucidate mechanism or mode of action
    Eaton, David L.
    Gallagher, Evan P.
    Hooper, Michael L.
    Schlenk, Dan
    Schmeider, Patricia
    Thompson, Claudia
    GENOMIC APPROACHES FOR CROSS-SPECIES EXTRAPOLATION IN TOXICOLOGY, 2007, : 77 - +
  • [27] Joint-action ecotoxicity of binary mixtures of glutaraldehyde and surfactants used in hospitals: Use of the Toxicity Index model and isoblogram representation
    Boillot, Clotilde
    Perrodin, Yves
    ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2008, 71 (01) : 252 - 259
  • [28] Joint Action Toxicity and Biochemical effects of Binary Mixtures of Forcados Light Crude Oil and Three Dispersants against Clarias gariepinus
    Sogbanmu, T. O.
    Otitoloju, A. A.
    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH, 2014, 8 (02) : 395 - 402
  • [29] Multi-class Mode of Action Classification of Toxic Compounds Using Logic Based Kernel Methods
    Lodhi, Huma
    Muggleton, Stephen
    Sternberg, Mike J. E.
    MOLECULAR INFORMATICS, 2010, 29 (8-9) : 655 - 664
  • [30] Prediction of liver toxicity and mode of action using metabolomics in vitro in HepG2 cells
    Ramirez, Tzutzuy
    Strigun, Alexander
    Verlohner, Andreas
    Huener, Hans-Albrecht
    Peter, Erik
    Herold, Michael
    Bordag, Natalie
    Mellert, Werner
    Walk, Tilmann
    Spitzer, Michael
    Jiang, Xiaoqi
    Sperber, Saskia
    Hofmann, Thomas
    Hartung, Thomas
    Kamp, Hennicke
    van Ravenzwaay, Ben
    ARCHIVES OF TOXICOLOGY, 2018, 92 (02) : 893 - 906