Novel ruthenium(II) polypyridyl complexes as G-quadruplex stabilisers and telomerase inhibitors

被引：22

作者：

Liao, Guoliang ^{[1
]}

Chen, Xiang ^{[1
]}

Wu, Jingheng ^{[1
]}

Qian, Chen ^{[1
]}

Wang, Hanqiang ^{[1
]}

Ji, Liangnian ^{[1
]}

Chao, Hui ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem & Chem Engn, State Key Lab Optoelect Mat & Technol, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China

来源：

DALTON TRANSACTIONS | 2014年 / 43卷 / 21期

关键词：

MOLECULAR LIGHT SWITCH; DNA-BINDING; CONFORMATIONAL SWITCH; TOPOISOMERASES I; LIGANDS; RECOGNITION; DUPLEX; METAL; RNA; TELOMESTATIN;

D O I：

10.1039/c3dt53547a

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Two novel ruthenium polypyridyl complexes, Ru[(bpy)(2)(pedppz)](2+) (1) and Ru[(bpy)(2)(pemitatp)](2+) (2) (bpy = 2'2-bipyridine, pdeppz = 10-(2-(piperidin-1-yl)ethoxy)dipyrido[3,2-a:2',3'-c] phenazine, pemitatp = 5-methoxy-1-(2-(piperidin-1-yl)ethyl)-isatino[1,2-b]-1,4,8,9-tetraazatriphenylene), bearing large planar pi-delocalized aromatic systems with flexible chains have been synthesised and characterised. As expected, these complexes show inhibition towards telomerase by inducing and stabilising the G-quadruplex structure.

引用

页码：7811 / 7819

页数：9

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