Novel ruthenium(II) polypyridyl complexes as G-quadruplex stabilisers and telomerase inhibitors

被引：22

作者：

Liao, Guoliang ^{[1
]}

Chen, Xiang ^{[1
]}

Wu, Jingheng ^{[1
]}

Qian, Chen ^{[1
]}

Wang, Hanqiang ^{[1
]}

Ji, Liangnian ^{[1
]}

Chao, Hui ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem & Chem Engn, State Key Lab Optoelect Mat & Technol, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China

来源：

DALTON TRANSACTIONS | 2014年 / 43卷 / 21期

关键词：

MOLECULAR LIGHT SWITCH; DNA-BINDING; CONFORMATIONAL SWITCH; TOPOISOMERASES I; LIGANDS; RECOGNITION; DUPLEX; METAL; RNA; TELOMESTATIN;

D O I：

10.1039/c3dt53547a

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Two novel ruthenium polypyridyl complexes, Ru[(bpy)(2)(pedppz)](2+) (1) and Ru[(bpy)(2)(pemitatp)](2+) (2) (bpy = 2'2-bipyridine, pdeppz = 10-(2-(piperidin-1-yl)ethoxy)dipyrido[3,2-a:2',3'-c] phenazine, pemitatp = 5-methoxy-1-(2-(piperidin-1-yl)ethyl)-isatino[1,2-b]-1,4,8,9-tetraazatriphenylene), bearing large planar pi-delocalized aromatic systems with flexible chains have been synthesised and characterised. As expected, these complexes show inhibition towards telomerase by inducing and stabilising the G-quadruplex structure.

引用

页码：7811 / 7819

页数：9

共 50 条

[21] Molecular modeling studies on G-quadruplex complexes of telomerase inhibitors: Structure-activity relationships
Read, MA
Wood, AA
Harrison, JR
Gowan, SM
Kelland, LR
Dosanjh, HS
Neidle, S
JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (22) : 4538 - 4546
[22] Selective, Disruptive Luminescent Ru(II) Polypyridyl Probes of G-Quadruplex
Holden, Lorcan
Gkika, Karmel S.
Burke, Christopher S.
Long, Conor
Keyes, Tia E.
INORGANIC CHEMISTRY, 2023, 62 (05) : 2213 - 2227
[23] Novel polypyridyl ruthenium(II) complexes for electroluminescence
Chuai, YT
Lee, DN
Zhen, CG
Min, JH
Kim, BH
Zou, DC
SYNTHETIC METALS, 2004, 145 (2-3) : 259 - 264
[24] Structural Studies Reveal Enantiospecific Recognition of a DNA G-Quadruplex by a Ruthenium Polypyridyl Complex
McQuaid, Kane
Abell, Holly
Gurung, Sarah P.
Allan, David R.
Winter, Graeme
Sorensen, Thomas
Cardin, David J.
Brazier, John A.
Cardin, Christine J.
Hall, James P.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 58 (29) : 9881 - 9885
[25] Visual specific luminescent probing of hybrid G-quadruplex DNA by a ruthenium polypyridyl complex
Liao, Guo-Liang
Chen, Xiang
Ji, Liang-Nian
Chao, Hui
CHEMICAL COMMUNICATIONS, 2012, 48 (87) : 10781 - 10783
[26] Water-soluble porphyrinoids as G-quadruplex binders and telomerase inhibitors
Ikawa, Yoshiya
Katsumata, Sho
Sakashita, Ryuichi
Sato, Shinobu
Takenaka, Shigeori
Furuta, Hiroyuki
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 2016, 20 (8-11) : 1041 - 1048
[27] Water-soluble porphyrinoids as G-quadruplex binders and telomerase inhibitors
Furuta, Hiroyuki
Ikawa, Yoshiya
Katsumata, Sho
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
[28] Synthesis of platinum (II) terpyridine complexes with the capability to stabilize the G-quadruplex and inhibit telomerase activity
Hoffbauer, Melissa R.
Shively, Raymond J.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 247
[29] G-quadruplex DNA as a target for drug discovery: Design of telomerase inhibitors based on G-quadruplex DNA structure and dynamics.
Kerwin, SM
Mamiya, B
Brian, C
Fletcher, T
Kern, JT
Thomas, PW
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2000, 219 : U6 - U6
[30] Ruthenium(II) complexes as apoptosis inducers by stabilizing c-myc G-quadruplex DNA
Zhang, Zhao
Wu, Qiong
Wu, Xiao-Hui
Sun, Fen-Yong
Chen, Lan-Mei
Chen, Jin-Chan
Yang, Shu-Ling
Mei, Wen-Jie
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 80 : 316 - 324

← 1 2 3 4 5 →