Novel ruthenium(II) polypyridyl complexes as G-quadruplex stabilisers and telomerase inhibitors

被引：22

作者：

Liao, Guoliang ^{[1
]}

Chen, Xiang ^{[1
]}

Wu, Jingheng ^{[1
]}

Qian, Chen ^{[1
]}

Wang, Hanqiang ^{[1
]}

Ji, Liangnian ^{[1
]}

Chao, Hui ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem & Chem Engn, State Key Lab Optoelect Mat & Technol, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China

来源：

DALTON TRANSACTIONS | 2014年 / 43卷 / 21期

关键词：

MOLECULAR LIGHT SWITCH; DNA-BINDING; CONFORMATIONAL SWITCH; TOPOISOMERASES I; LIGANDS; RECOGNITION; DUPLEX; METAL; RNA; TELOMESTATIN;

D O I：

10.1039/c3dt53547a

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Two novel ruthenium polypyridyl complexes, Ru[(bpy)(2)(pedppz)](2+) (1) and Ru[(bpy)(2)(pemitatp)](2+) (2) (bpy = 2'2-bipyridine, pdeppz = 10-(2-(piperidin-1-yl)ethoxy)dipyrido[3,2-a:2',3'-c] phenazine, pemitatp = 5-methoxy-1-(2-(piperidin-1-yl)ethyl)-isatino[1,2-b]-1,4,8,9-tetraazatriphenylene), bearing large planar pi-delocalized aromatic systems with flexible chains have been synthesised and characterised. As expected, these complexes show inhibition towards telomerase by inducing and stabilising the G-quadruplex structure.

引用

页码：7811 / 7819

页数：9

共 50 条

[1] Polypyridyl Complexes of Ruthenium(II): Stabilization of G-quadruplex DNA and Inhibition of Telomerase Activity
Liu, Du
Liu, Yanan
Wang, Chuan
Shi, Shuo
Sun, Dongdong
Gao, Feng
Zhang, Qianling
Liu, Jie
CHEMPLUSCHEM, 2012, 77 (07): : 551 - 562
[2] Chiral Ruthenium(II) Polypyridyl Complexes: Stabilization of G-Quadruplex DNA, Inhibition of Telomerase Activity and Cellular Uptake
Yu, Qianqian
Liu, Yanan
Wang, Chuan
Sun, Dongdong
Yang, Xingcheng
Liu, Yanyu
Liu, Jie
PLOS ONE, 2012, 7 (12):
[3] Ruthenium(II) polypyridyl complexes as G-quadruplex inducing and stabilizing ligands in telomeric DNA
Yu, Qianqian
Liu, Yanyu
Zhang, Jingnan
Yang, Fang
Sun, Dongdong
Liu, Du
Zhou, Yanhui
Liu, Jie
METALLOMICS, 2013, 5 (03) : 222 - 231
[4] Metal-containing stabilisers of G-quadruplex DNA as telomerase inhibitors.
Reed, JE
Arola, A
Vilar, R
Neidle, S
CLINICAL CANCER RESEARCH, 2005, 11 (24) : 9051S - 9051S
[5] Stabilization of G-quadruplex DNA and inhibition of telomerase activity studies of ruthenium(II) complexes
Li, Qianli
Zhang, Jingnan
Yang, Licong
Yu, Qianqian
Chen, Qingchang
Qin, Xiuying
Le, Fangling
Zhang, Qianling
Liu, Jie
JOURNAL OF INORGANIC BIOCHEMISTRY, 2014, 130 : 122 - 129
[6] Novel platinum complexes as efficient G-quadruplex DNA binders and telomerase inhibitors
Wei, Chunying
Wen, Ye
Wang, Junhong
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2013, 55 : 185 - 192
[7] Ruthenium(II) polypyridyl complexes as dual inhibitors of telomerase and topoisomerase
Liao, Guoliang
Chen, Xiang
Wu, Jingheng
Qian, Chen
Wang, Yi
Ji, Liangnian
Chao, Hui
DALTON TRANSACTIONS, 2015, 44 (34) : 15145 - 15156
[8] Dinuclear Ruthenium(II) Complexes as G-Quadruplex DNA
Xu, Li
Chao, Hui
Ji, Liangnian
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2009, 26 (06): : 879 - 879
[9] The Design of G-quadruplex Ligands as Telomerase Inhibitors
Cuesta, Javier
Read, Martin A.
Neidle, Stephen
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2003, 3 (01) : 11 - 21
[10] Two novel fan-shaped trinuclear Pt(ii) complexes act as G-quadruplex binders and telomerase inhibitors
Xu, Cui-Xia
Liu, Liu-Yi
Lv, Bei
Zhao, Hao-Yu
Cao, Qian
Zhai, Teng
Mao, Zong-Wan
DALTON TRANSACTIONS, 2020, 49 (27) : 9322 - 9329

← 1 2 3 4 5 →